Zhang Jia-jia, Zhu Yuan, Yu Jiang-nan, Xu Xi-ming
Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):3932-6.
Recent years, chemical constituents from spice volatile oils have gained worldwide concern owing to its multiple pharmacological effects and safety for using as the natural antibacterial agents. However, their poor dissolution, strong volatility, serious irritation, weak stability, easy oxidation and low bioavailability characteristics are the major obstacle in the preparation of effective oral formulation and practical application. Therefore, there is an urgent need to select a novel carrier system that can delivery the chemical constituents from spice volatile oils more efficiently with improving their stability as well as alleviating the irritation, and develop the functional food, health products and even medicine for exerting their pharmacological effects, which also is the focus and nodus of the research on their application. This review presents recent systematic studies on their novel carrier systems, including cyclodextrin inclusion complex, liposomes, nanoemulsions, nanoparticles, solid dispersion and so on, and summarizes the characteristics, application range and problems of each novel carrier systems, in order to provide some beneficial thoughts in further developing new products of chemical constituents from spice volatile oils.
近年来，香料挥发油中的化学成分因其多种药理作用以及作为天然抗菌剂使用的安全性而受到全球关注。然而，它们溶解性差、挥发性强、刺激性大、稳定性弱、易氧化且生物利用度低等特性，是制备有效的口服制剂及实际应用中的主要障碍。因此，迫切需要选择一种新型载体系统，能够更有效地递送香料挥发油中的化学成分，同时提高其稳定性并减轻刺激性，开发出发挥其药理作用的功能性食品、保健品甚至药物，这也是其应用研究的重点和难点。本文综述了近年来对其新型载体系统的系统研究，包括环糊精包合物、脂质体、纳米乳剂、纳米颗粒、固体分散体等，并总结了每种新型载体系统的特点、应用范围及存在的问题，以期为进一步开发香料挥发油化学成分的新产品提供有益思路。
