Severino Patricia, Andreani Tatiana, Chaud Marco V, Benites Cibelem I, Pinho Samantha C, Souto Eliana B
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Polo das Ciencias da Saude, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Curr Pharm Biotechnol. 2015;16(4):365-70. doi: 10.2174/1389201016666150206111253.
Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflammation, cancer and to treat microbial infections. However, there are some physicochemical properties that may limit their use as active compounds in several formulations, such as high volatility, low-appealing organoleptic properties, low bioavailability and physicochemical instability, as result of exposure to light, oxygen and high temperatures. To overcome these limitations, lipid colloidal carriers (e.g. liposomes, solid lipid nanoparticles (SLN), self nanoemulsified drug delivery systems (SNEDDS)) have been pointed out as suitable carriers to improve bioavailability, low solubility, taste, flavor and long-term storage of sensitive compounds. This paper reviews the potential beneficial effects of formulating essential oils in pharmaceutical applications using colloidal carriers as delivery systems.
精油作为新型药物剂型的有前景成分，已引起越来越多的关注。据报道，这些油不仅具有可生物降解的特性，其活性成分还能产生协同效应。此外，精油在糖尿病、炎症、癌症治疗以及微生物感染治疗方面可能也具有治疗作用。然而，精油的一些物理化学性质可能会限制其在多种制剂中作为活性化合物的应用，例如高挥发性、感官性质不佳、低生物利用度以及由于暴露于光、氧气和高温而导致的物理化学不稳定性。为克服这些限制，脂质胶体载体（如脂质体、固体脂质纳米粒（SLN）、自纳米乳化药物递送系统（SNEDDS））已被指出是改善敏感化合物生物利用度、低溶解度、味道、风味和长期储存的合适载体。本文综述了使用胶体载体作为递送系统在药物应用中配制精油的潜在有益效果。
