Nielsen I, Steiness E, Hesse B
Acta Med Scand. 1978;203(5):415-8. doi: 10.1111/j.0954-6820.1978.tb14898.x.
The changes in plasma renin activity (PRA) during short-term salt depletion (and peroral furosemide on the first day) and after bolus injection of propranolol were compared to the change during long-term treatment with diuretic and with propranolol in 19 patients with benign primary hypertension. A highly significant correlation was found between PRA on short-term and long-term salt depletion (r=0.02). A highly significant correlation was likewise found between initial PRA and decrement of PRA after bolus injection of or long-term treatment with propranolol. Only a weak inverse correlation was found between PRA reached during short-term salt depletion or long-term diuretic treatment and the fall in diastolic BP during long-term treatment (r=0.60). No significant correlation was found between decrease in PRA on propranolol (bolus/long-term) and diastolic BP reduction. It is concluded that the short-term PRA response to salt depletion and propranolol in the individual patient gives a good prediction of the PRA level on long-term diuretic or propranolol treatment, but is of no value in predicting the BP reduction during treatment.
对19例原发性良性高血压患者在短期限盐（第一天口服速尿）及静脉注射普萘洛尔后血浆肾素活性（PRA）的变化，与长期使用利尿剂和普萘洛尔治疗期间的变化进行了比较。发现短期和长期限盐时的PRA之间存在高度显著的相关性（r = 0.02）。同样，在静脉注射普萘洛尔或长期使用普萘洛尔治疗后，初始PRA与PRA的降低之间也存在高度显著的相关性。在短期限盐或长期利尿剂治疗期间达到的PRA与长期治疗期间舒张压的下降之间仅发现微弱的负相关（r = 0.60）。在普萘洛尔（静脉注射/长期）治疗时PRA的降低与舒张压降低之间未发现显著相关性。得出的结论是，个体患者对限盐和普萘洛尔的短期PRA反应能很好地预测长期使用利尿剂或普萘洛尔治疗时的PRA水平，但对预测治疗期间的血压降低没有价值。
