Bravo E L, Tarazi R C, Dustan H P, Lewis J W
Circ Res. 1975 Jun;36(6 Suppl 1):241-7. doi: 10.1161/01.res.36.6.241.
Studies were carried out in 69 patients with essential hypertension to examine the relationship between changes in plasma renin activity (PRA) and arterial pressure (BP) in response to a beta-adrenergic blocking agent, propranolol. PRA had no consistent relationship with BP during treatment, either in patients receiving propranolol alone (r = 0.12) or in those receiving a combination of diuretics and propranolol (r = 0.18). Furthermore, long-term beta-adrenergic blockade failed to inhibit increases of PRA induced by diuretics or rapid sodium depletion. These results indicate that (1) beta-adrenergic blockade can reduce BP by mechanisms other than PRA suppression; and (2) the beta-adrenergic nervous system is important, but not essential, for renin release.
对69例原发性高血压患者进行了研究，以探讨血浆肾素活性（PRA）变化与动脉压（BP）对β-肾上腺素能阻滞剂普萘洛尔反应之间的关系。在治疗期间，无论是单独接受普萘洛尔治疗的患者（r = 0.12）还是接受利尿剂和普萘洛尔联合治疗的患者（r = 0.18），PRA与BP均无一致关系。此外，长期β-肾上腺素能阻滞未能抑制利尿剂或快速钠耗竭诱导的PRA升高。这些结果表明：（1）β-肾上腺素能阻滞可通过抑制PRA以外的机制降低血压；（2）β-肾上腺素能神经系统对肾素释放很重要，但并非必不可少。
