LaHoste G J, Neveu P J, Mormède P, Le Moal M
Laboratoire de Psychobiologie des Compartements, I.N.S.E.R.M. Unité 259, Bordeaux (France).
Brain Res. 1989 Mar 27;483(1):123-9. doi: 10.1016/0006-8993(89)90042-5.
Female rats were subjected to unilateral left or right, bilateral, or sham ablation of the cerebral cortex. Eight weeks after surgery, the rats were sacrificed by decapitation and spleen cells were grown in culture for 96 h in the presence or absence of the T-cell mitogen concanavalin A or the B-cell mitogen lipopolysaccharide. Mitogenesis was determined by the addition of [3H]thymidine 24 h prior to harvesting. Both T- and B-cell mitogenesis were significantly depressed in subjects bearing cortical ablations in the right hemisphere, whereas left hemisphere ablation was without reliable effect. Prolactin in plasma collected at sacrifice was elevated in rats bearing right but not left hemisphere ablation and was significantly negatively correlated with both T- and B-cell immune responses. These results demonstrate a lateralized modulatory influence of cerebral cortex on immune function in female rats and they implicate elevated prolactin levels as a possible mediator of this effect.
对雌性大鼠进行单侧左或右、双侧或假手术切除大脑皮层。术后8周，通过断头处死大鼠，脾细胞在有或无T细胞丝裂原伴刀豆球蛋白A或B细胞丝裂原脂多糖存在的情况下培养96小时。在收获前24小时加入[3H]胸腺嘧啶核苷来测定有丝分裂原的生成。右半球有皮层切除的大鼠中，T细胞和B细胞的有丝分裂原生成均显著降低，而左半球切除则无可靠影响。处死时收集的血浆中催乳素水平在右半球切除的大鼠中升高，而左半球切除的大鼠中则未升高，且与T细胞和B细胞免疫反应均呈显著负相关。这些结果表明大脑皮层对雌性大鼠免疫功能有侧化调节作用，并提示催乳素水平升高可能是这种作用的介导因素。
