LaHoste G J, Mormède P, Rivet J M, Le Moal M
Laboratoire de Psychobiologie des Comportements Adaptatifs, I.N.S.E.R.M., U259, Bordeaux, France.
Brain Res. 1988 Dec 6;474(2):296-308. doi: 10.1016/0006-8993(88)90443-x.
The purpose of the present study was to search for possible relationships among diverse measures of behavioral laterality in a non-human species or to identify an index of laterality that was predictive of other non-lateralized functions. Several indices of behavioral laterality and open field activity were assessed in male and female rats before and after asymmetric neocortical ablations. Plasma adrenocorticotropin, corticosterone, and prolactin were measured following stress at sacrifice. Sex-dependent population-level lateral biases were observed preoperatively in the choice of arms in a T-maze and initial direction out of a corner of an open field. Unilateral left neocortical ablation induced a leftward bias in the T-maze in both male and female rats. The direction of rotation following the peripheral administration of amphetamine was correlated with: (a) the degree of sensitization to amphetamine; (b) preoperative open field activity in females; (c) the induction of hyperactivity following right neocortical ablation in males; (d) rotational responses to amphetamine in male rats sustaining bilateral ablations; and (e) the effect of left neocortical ablation on prolactin levels in males. We propose that these data provide new evidence for distinct patterns of brain organization in rats differentiated by a measure of inherent cerebral laterality.
本研究的目的是探寻非人类物种中各种行为偏侧性测量指标之间可能存在的关系，或者确定一种能够预测其他非偏侧性功能的偏侧性指标。在不对称新皮质切除术前和术后，对雄性和雌性大鼠的几种行为偏侧性指标和旷场活动进行了评估。在处死后应激状态下测量血浆促肾上腺皮质激素、皮质酮和催乳素。术前在T迷宫中选择臂部以及从旷场一角出来的初始方向上，观察到了性别依赖性的群体水平偏侧性偏差。单侧左新皮质切除在雄性和雌性大鼠的T迷宫中均诱导出向左的偏差。外周注射苯丙胺后的旋转方向与以下因素相关：(a) 对苯丙胺的敏感程度；(b) 雌性大鼠术前的旷场活动；(c) 雄性大鼠右新皮质切除后多动的诱导；(d) 双侧切除的雄性大鼠对苯丙胺的旋转反应；以及(e) 左新皮质切除对雄性大鼠催乳素水平的影响。我们认为，这些数据为通过一种内在脑偏侧性测量指标区分的大鼠不同脑组织结构模式提供了新证据。
