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环磷酸腺苷（cAMP）信号通路作为自身免疫性疾病和炎症性疾病的治疗靶点

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases.

作者信息

Raker Verena Katharina, Becker Christian, Steinbrink Kerstin

机构信息

Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University Mainz , Mainz , Germany.

出版信息

Front Immunol. 2016 Mar 31;7:123. doi: 10.3389/fimmu.2016.00123. eCollection 2016.

DOI:10.3389/fimmu.2016.00123
PMID:27065076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4814577/
Abstract

Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.

摘要

核苷酸信号分子有助于细胞通路的调节。在免疫系统中，环磷酸腺苷（cAMP）作为先天性和适应性免疫细胞功能的有效调节剂已得到充分证实。中断或增强cAMP生成或作用的治疗策略在自身免疫性和炎性疾病中具有免疫调节潜力。在此，我们概述了环磷酸腺苷轴及其作为免疫功能调节剂的作用，并讨论了针对这些过程进行干预的临床和转化相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/2825472f7049/fimmu-07-00123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/e88d22db8abb/fimmu-07-00123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/32c1c5705f58/fimmu-07-00123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/ff9250646e9f/fimmu-07-00123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/2825472f7049/fimmu-07-00123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/e88d22db8abb/fimmu-07-00123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/32c1c5705f58/fimmu-07-00123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/ff9250646e9f/fimmu-07-00123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f589/4814577/2825472f7049/fimmu-07-00123-g004.jpg

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