细胞减灭术及腹腔热灌注化疗治疗腹膜转移瘤的并发症
Complications of Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases.
作者信息
Mehta Sanket S, Gelli Maxilliano, Agarwal Deepesh, Goéré Diane
机构信息
Division of Peritoneal Surface Oncology, Saifee Hospital, MK marg, Charni road, Mumbai, Girgaum 400004 India.
Department of Surgical Oncology, Gustave Roussy, Cancer Campus, 114, Av Edouard Vaillant, 94805 Villejuif, Cedex France.
出版信息
Indian J Surg Oncol. 2016 Jun;7(2):225-9. doi: 10.1007/s13193-016-0504-6. Epub 2016 Feb 10.
Abstract
The combined treatment concept of cytoreductive surgery (CRS) and Hyperthermic intraperitoneal chemotherapy (HIPEC) has shown to be an efficient therapeutic option for selected patients with primary and secondary peritoneal carcinomatosis (PC). This strategy represents the standard of care for diseases like pseudomyxoma peritonei and peritoneal mesothelioma, and offers the best long-term results for PC from colorectal cancer. Despite these results, skepticism exists regarding this therapeutic approach partly because of its perceived high toxicity. In this article, we review the current evidence on complications that can occur after CRS and HIPEC and the risk factors associated with increased incidence of morbidity and mortality.
摘要
细胞减灭术（CRS）和腹腔内热灌注化疗（HIPEC）的联合治疗理念已被证明是治疗原发性和继发性腹膜癌（PC）特定患者的有效治疗选择。该策略是腹膜假黏液瘤和腹膜间皮瘤等疾病治疗的标准方法，并且为结直肠癌引起的PC提供了最佳长期疗效。尽管有这些结果，但对于这种治疗方法仍存在怀疑，部分原因是其被认为毒性较高。在本文中，我们回顾了目前关于CRS和HIPEC术后可能发生的并发症以及与发病率和死亡率增加相关的危险因素的证据。
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