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一例免疫功能正常患者的嗜皮诺卡菌肺炎和纵隔炎病例。

A Case of Nocardia farcinica Pneumonia and Mediastinitis in an Immunocompetent Patient.

作者信息

Kim Jinyoung, Kang Minkyu, Kim Juri, Jung Sohee, Park Junhung, Lee Dongkyu, Yoon Heejung

机构信息

Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.

Department of Infectious Diseases, Seoul Metropolitan Government Seobuk Hospital, Seoul, Korea.

出版信息

Tuberc Respir Dis (Seoul). 2016 Apr;79(2):101-3. doi: 10.4046/trd.2016.79.2.101. Epub 2016 Mar 31.

Abstract

Nocardia species are aerobic, gram-positive pathogens found worldwide in soil. Nocardia is considered an opportunistic pathogen, and its infection mostly occurs in immunocompromised patients. We report a case of Nocardia farcinica induced mediastinitis and pneumonia that occurred in a 64-year-old male patient who had no significant medical history except for hypertension. He visited another hospital with a complaint of dyspnea and left chest wall pain. The symptoms arose 7 days ago without any trauma and they worsened. A mediastinal mass was found on computed tomography scan. After being transferred to our hospital for further evaluation, he was diagnosed with mediastinitis and pneumonia. As N. farcinica was found to be the causative organism by 16S rRNA sequencing, proper antibiotic therapy including trimethoprim/sulfamethoxazole was initiated immediately. After this, the patient improved and he was discharged. If an infection has a disseminating course, nocardiosis cannot be excluded even in immunocompetent patients. Once the diagnosis is established, prompt antibiotic therapy should be performed based on the severity.

摘要

诺卡菌属是需氧的革兰氏阳性病原体,在世界各地的土壤中均有发现。诺卡菌被认为是一种机会性病原体,其感染主要发生在免疫功能低下的患者中。我们报告一例由豚鼠耳炎诺卡菌引起的纵隔炎和肺炎病例,该病例发生在一名64岁男性患者身上,除高血压外无其他重大病史。他因呼吸困难和左胸壁疼痛前往另一家医院就诊。这些症状于7天前出现,无任何外伤史且逐渐加重。计算机断层扫描发现纵隔肿块。转至我院进一步评估后,他被诊断为纵隔炎和肺炎。通过16S rRNA测序发现豚鼠耳炎诺卡菌为致病微生物后,立即开始使用包括甲氧苄啶/磺胺甲恶唑在内的适当抗生素进行治疗。此后,患者病情好转并出院。如果感染呈播散性病程,即使在免疫功能正常的患者中也不能排除诺卡菌病。一旦确诊,应根据病情严重程度立即进行抗生素治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f4/4823182/e097a05fc3c8/trd-79-101-g001.jpg

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