Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Glenn Center for Research on Aging, University of California, Berkeley, Berkeley, CA, USA.
Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Glenn Center for Research on Aging, University of California, Berkeley, Berkeley, CA, USA.
Trends Endocrinol Metab. 2016 May;27(5):294-303. doi: 10.1016/j.tem.2016.03.007. Epub 2016 Apr 8.
Sensory perception comprises gustatory (taste) and olfactory (smell) modalities as well as somatosensory (pain, heat, and tactile mechanosensory) inputs, which are detected by a multitude of sensory receptors. These sensory receptors are contained in specialized ciliated neurons where they detect changes in environmental conditions and participate in behavioral decisions ranging from food choice to avoiding harmful conditions, thus insuring basic survival in metazoans. Recent genetic studies, however, indicate that sensory perception plays additional physiological functions, notably influencing energy homeostatic processes and longevity through neuronal circuits originating from sensory tissues. Here we review how these findings are redefining metabolic signaling and establish a prominent role of sensory neuroendocrine processes in controlling health span and lifespan, with a goal of translating this knowledge towards managing age-associated diseases.
感觉感知包括味觉（味觉）和嗅觉（嗅觉）模式以及躯体感觉（疼痛、热和触觉机械感觉）输入，这些输入由多种感觉受体检测到。这些感觉受体包含在专门的纤毛神经元中，在那里它们检测环境条件的变化，并参与从食物选择到避免有害条件的行为决策，从而确保后生动物的基本生存。然而，最近的遗传研究表明，感觉感知还具有其他生理功能，特别是通过源自感觉组织的神经元回路影响能量稳态过程和寿命。在这里，我们回顾了这些发现如何重新定义代谢信号，并确立了感觉神经内分泌过程在控制健康寿命和寿命方面的突出作用，目的是将这些知识转化为管理与年龄相关的疾病。
