Lohuis Peter J F M, Joshi Anil, Borggreven Pepijn A, Vermeeren Lenka, Zupan-Kajcovski Biljana, Al-Mamgani Abrahim, Balm Alfons J M
Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Diakonessenhuis Hospital, Utrecht, The Netherlands.
Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3881-3889. doi: 10.1007/s00405-016-4039-9. Epub 2016 Apr 11.
With exponentially increasing numbers of basal cell carcinoma (BCC) of the head and neck region, also the locally advanced BCCs are increasing in number. These tumours are associated with aggressive biological behaviour with invasion of soft tissues, organs or bone and present with wide variation in management strategies. The objectives of the study was to describe the biological behaviour of aggressive BCCs and their clinical presentation in the head and neck region with a series of cases treated in our tertiary hospital, discuss management plans of such complex cases in terms of surgical planning and reconstruction. A series of five cases of aggressive BCC in the head and neck region with involvement of organs such as nose, orbit, temporal bone, facial nerve, paranasal sinuses and mandible was studied. Locally advanced, aggressive BCC should be evaluated and treated as head and neck tumours. Multidisciplinary team (MDT) discussion is advisable wherein the strategies on surgical excision, reconstruction options, facial nerve rehabilitation, indications for prosthesis and further adjuvant treatment such as radiotherapy and chemotherapy are carefully planned.
随着头颈部基底细胞癌（BCC）的数量呈指数级增长，局部晚期BCC的数量也在增加。这些肿瘤具有侵袭性生物学行为，可侵犯软组织、器官或骨骼，其治疗策略差异很大。本研究的目的是通过我院治疗的一系列病例，描述侵袭性BCC在头颈部的生物学行为及其临床表现，并从手术规划和重建方面讨论此类复杂病例的管理计划。研究了一系列5例头颈部侵袭性BCC病例，这些病例累及鼻子、眼眶、颞骨、面神经、鼻窦和下颌骨等器官。局部晚期、侵袭性BCC应作为头颈部肿瘤进行评估和治疗。建议进行多学科团队（MDT）讨论，仔细规划手术切除策略、重建方案、面神经康复、假体植入指征以及放疗和化疗等进一步辅助治疗。
