头颈部局部侵袭性基底细胞癌手术后的肿瘤学结果。

Oncologic outcomes after surgery for locally aggressive basal cell carcinoma of the head and neck.

机构信息

Division of Otolaryngology-Head and Neck Surgery, The University of California, Davis , Sacramento, California, U.S.A.

出版信息

Laryngoscope. 2020 Jan;130(1):115-119. doi: 10.1002/lary.27882. Epub 2019 Mar 5.

DOI:10.1002/lary.27882

PMID:30835833

Abstract

OBJECTIVE

Although basal cell carcinoma (BCC) is the most common skin cancer, locally aggressive BCC of the head and neck is rare and not well studied.

STUDY DESIGN

Retrospective review of patients who underwent primary surgical resection of locally aggressive head and neck BCC at a single tertiary academic center.

RESULTS

Eighty-seven patients with 98 tumors demonstrated a 5-year Kaplan-Meier estimated recurrence-free survival of 64.5%, overall survival of 83.3%, and disease-specific survival of 98.3%. Intraoperative positive frozen section margin was a strong independent predictor of local recurrence (hazard ratio 6.88, P = 0.038) and was more likely to occur in tumors previously treated with radiation (odds ratio 6.47 = 0.05).

CONCLUSION

Locally aggressive BCCs of the head and neck have high rates of local recurrence but low disease-specific mortality when treated with primary surgery and selected use of adjuvant therapy. Intraoperative positive frozen section margin is a strong independent predictor of local recurrence and is more likely in tumors that were previously treated with radiation therapy.

LEVEL OF EVIDENCE

4 Laryngoscope, 130:115-119, 2020.

摘要

目的

尽管基底细胞癌（BCC）是最常见的皮肤癌，但头颈部局部侵袭性 BCC 较为罕见，研究也较少。

研究设计

对在单一三级学术中心行原发性手术切除局部侵袭性头颈部 BCC 的患者进行回顾性研究。

结果

87 例患者的 98 个肿瘤 5 年 Kaplan-Meier 无复发生存率估计值为 64.5%，总生存率为 83.3%，疾病特异性生存率为 98.3%。术中冰冻切片阳性切缘是局部复发的强独立预测因素（风险比 6.88，P=0.038），并且更可能发生于先前接受过放射治疗的肿瘤中（比值比 6.47=0.05）。