Raiborg Camilla, Wenzel Eva M, Pedersen Nina M, Stenmark Harald
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway Centre of Molecular Inflammation Research, Faculty of Medicine, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
Biochem Soc Trans. 2016 Apr 15;44(2):425-30. doi: 10.1042/BST20150190.
Cellular membranes communicate extensively via contact sites that form between two membranes. Such sites allow exchange of specific ions, lipids or proteins between two compartments without content mixing, thereby preserving organellar architecture during the transfer process. Even though the molecular compositions of membrane contact sites are diverse, it is striking that several of these sites, including contact sites between the endoplasmic reticulum (ER) and endosomes, Golgi and the plasma membrane (PM), and contact sites between lysosomes and peroxisomes, contain phosphorylated derivatives of phosphatidylinositol known as phosphoinositides. In this mini-review we discuss the involvement and functions of phosphoinositides in membrane contact sites.
细胞膜通过两个膜之间形成的接触位点进行广泛的通讯。这些位点允许两个区室之间交换特定的离子、脂质或蛋白质，而不会使内容物混合，从而在转运过程中保持细胞器的结构。尽管膜接触位点的分子组成多种多样，但令人惊讶的是，其中一些位点，包括内质网（ER）与内体之间的接触位点、高尔基体与质膜（PM）之间的接触位点，以及溶酶体与过氧化物酶体之间的接触位点，都含有磷脂酰肌醇的磷酸化衍生物，即磷酸肌醇。在这篇小型综述中，我们讨论了磷酸肌醇在膜接触位点中的作用和功能。
