说得对！STARD3和STARD3NL将内质网与内体相连。

Touché! STARD3 and STARD3NL tether the ER to endosomes.

作者信息

Wilhelm Léa P, Tomasetto Catherine, Alpy Fabien

机构信息

Functional Genomics and Cancer Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 1 rue Laurent Fries, 67404 Illkirch, France Institut National de la Santé et de la Recherche Médicale (INSERM), U 964, 67404 Illkirch, France Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France Université de Strasbourg, 67404 Illkirch, France.

出版信息

Biochem Soc Trans. 2016 Apr 15;44(2):493-8. doi: 10.1042/BST20150269.

DOI:10.1042/BST20150269

PMID:27068960

Abstract

Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange, are scaffolded by specific complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain-3] and its close paralogue STARD3NL (STARD3 N-terminal like) are involved in the formation of contacts between late-endosomes and the endoplasmic reticulum (ER). The lipid transfer protein (LTP) STARD3 and STARD3NL, which are both anchored on the limiting membrane of late endosomes (LEs), interact with ER-anchored VAP [VAMP (vesicle-associated membrane protein)-associated protein] (VAP-A and VAP-B) proteins. This direct interaction allows ER-endosome contact formation. STARD3 or STARD3NL-mediated ER-endosome contacts, which affect endosome dynamics, are believed to be involved in cholesterol transport.

摘要

膜接触位点（MCSs）是不同细胞器的膜紧密并列的亚细胞区域。这些细胞的特殊区域参与细胞器间代谢物交换，由特定复合物构成支架。STARD3 [类固醇生成急性调节蛋白（StAR）相关脂质转移结构域3]及其紧密同源物STARD3NL（类STARD3 N端）参与晚期内体与内质网（ER）之间接触的形成。脂质转移蛋白（LTP）STARD3和STARD3NL均锚定在晚期内体（LEs）的界膜上，与内质网锚定的VAP [囊泡相关膜蛋白（VAMP）相关蛋白]（VAP-A和VAP-B）蛋白相互作用。这种直接相互作用使得内质网-内体接触得以形成。据信，影响内体动态的STARD3或STARD3NL介导的内质网-内体接触参与胆固醇转运。