Fiocchi Serena, Longhi Michela, Ravazzani Paolo, Roth Yiftach, Zangen Abraham, Parazzini Marta
CNR Consiglio Nazionale delle Ricerche, Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni IEIIT, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Department of Life Sciences, Ben-Gurion University of the Negev, 84105 Beersheba, Israel.
Comput Math Methods Med. 2016;2016:9039613. doi: 10.1155/2016/9039613. Epub 2016 Mar 16.
In the last few years, deep transcranial magnetic stimulation (dTMS) has been used for the treatment of depressive disorders, which affect a broad category of people, from adolescents to aging people. To facilitate its clinical application, particular shapes of coils, including the so-called Hesed coils, were designed. Given their increasing demand and the lack of studies which accurately characterize their use, this paper aims to provide a picture of the distribution of the induced electric field in four realistic human models of different ages and gender. In detail, the electric field distributions were calculated by using numerical techniques in the brain structures potentially involved in the progression of the disease and were quantified in terms of both amplitude levels and focusing power of the distribution. The results highlight how the chosen Hesed coil (H7 coil) is able to induce the maxima levels of E mainly in the prefrontal cortex, particularly for the younger model. Moreover, growing levels of induced electric fields with age were found by going in deep in the brain, as well as a major capability to penetrate in the deepest brain structures with an electric field higher than 50%, 70%, and 90% of the peak found in the cortex.
在过去几年中，深部经颅磁刺激（dTMS）已被用于治疗抑郁症，抑郁症影响着从青少年到老年人的广泛人群。为便于其临床应用，设计了特殊形状的线圈，包括所谓的赫塞德线圈。鉴于其需求不断增加且缺乏准确描述其使用情况的研究，本文旨在呈现不同年龄和性别的四种真实人体模型中感应电场的分布情况。具体而言，通过数值技术计算了可能与疾病进展相关的脑结构中的电场分布，并从分布的幅度水平和聚焦能力两方面进行了量化。结果表明，所选的赫塞德线圈（H7线圈）能够主要在前额叶皮质诱导出最大电场水平，尤其是对于较年轻的模型。此外，随着深入大脑，发现感应电场水平随年龄增长，并且具有以高于皮质中峰值的50%、70%和90%的电场穿透最深脑结构的更强能力。
