Department of Information Technology, Ghent University-Imec, Ghent, Belgium.
Biomed Res Int. 2018 Jun 5;2018:7061420. doi: 10.1155/2018/7061420. eCollection 2018.
Stimulation of deep brain structures by transcranial magnetic stimulation (TMS) is a method for activating deep neurons in the brain and can be beneficial for the treatment of psychiatric and neurological disorders. To numerically investigate the possibility for deeper brain stimulation (electric fields reaching the hippocampus, the nucleus accumbens, and the cerebellum), combined TMS coils using the double-cone coil with the Halo coil (HDA) were modeled and investigated. Numerical simulations were performed using MIDA: a new multimodal imaging-based detailed anatomical model of the human head and neck. The 3D distributions of magnetic flux density and electric field were calculated. The percentage of volume of each tissue that is exposed to electric field amplitude equal or greater than 50% of the maximum amplitude of E in the cortex for each coil was calculated to quantify the electric field spread (V50). Results show that only the HDA coil can spread electric fields to the hippocampus, the nucleus accumbens, and the cerebellum with V50 equal to 0.04%, 1.21%, and 6.2%, respectively.
经颅磁刺激（TMS）刺激大脑深部结构是一种激活大脑深部神经元的方法，可有益于治疗精神和神经疾病。为了数值研究更深层次脑刺激（电场到达海马体、伏隔核和小脑）的可能性，使用双锥线圈和 Halo 线圈（HDA）的组合 TMS 线圈进行了建模和研究。使用 MIDA（一种新的基于多模态成像的人体头部和颈部详细解剖模型）进行数值模拟。计算了磁通密度和电场的 3D 分布。为了量化电场的传播（V50），计算了每个组织的体积百分比，这些组织的电场幅度等于或大于皮层中 E 的最大幅度的 50%。结果表明，只有 HDA 线圈可以将电场传播到海马体、伏隔核和小脑，V50 分别为 0.04%、1.21%和 6.2%。
