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骨髓基质细胞对缺血性中风的治疗作用

Therapy Effects of Bone Marrow Stromal Cells on Ischemic Stroke.

作者信息

Ye Xinchun, Hu Jinxia, Cui Guiyun

机构信息

Department of Neurology, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province 221006, China.

出版信息

Oxid Med Cell Longev. 2016;2016:7682960. doi: 10.1155/2016/7682960. Epub 2016 Mar 16.

DOI:10.1155/2016/7682960
PMID:27069533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4812472/
Abstract

Stroke is the second most common cause of death and major cause of disability worldwide. Recently, bone marrow stromal cells (BMSCs) have been shown to improve functional outcome after stroke. In this review, we will focus on the protective effects of BMSCs on ischemic brain and the relative molecular mechanisms underlying the protective effects of BMSCs on stroke.

摘要

中风是全球第二大常见死因和致残的主要原因。最近，骨髓基质细胞（BMSCs）已被证明可改善中风后的功能结局。在本综述中，我们将重点关注骨髓基质细胞对缺血性脑的保护作用以及骨髓基质细胞对中风保护作用的相关分子机制。

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Therapy Effects of Bone Marrow Stromal Cells on Ischemic Stroke.骨髓基质细胞对缺血性中风的治疗作用
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Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice.延迟经鼻给予低氧预处理的骨髓间充质干细胞增强了缺血性脑卒中后细胞归巢和治疗效果。
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Ann Transl Med. 2020 Mar;8(6):390. doi: 10.21037/atm.2020.03.144.
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Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke.人尿液来源干细胞衍生的外泌体通过 miR-26a/HDAC6 轴促进缺血性脑卒中后的神经发生。
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本文引用的文献

1
Poststroke Cell Therapy of the Aged Brain.老年脑卒后脑细胞治疗
Neural Plast. 2015;2015:839638. doi: 10.1155/2015/839638. Epub 2015 Aug 11.
2
Intranasal administration of human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke.经鼻给予人脐带间充质干细胞条件培养基可增强中风后的血管重塑。
Brain Res. 2015 Oct 22;1624:489-496. doi: 10.1016/j.brainres.2015.08.003. Epub 2015 Aug 13.
3
Role of complement and complement regulatory proteins in the complications of diabetes.补体及补体调节蛋白在糖尿病并发症中的作用
Endocr Rev. 2015 Jun;36(3):272-88. doi: 10.1210/er.2014-1099. Epub 2015 Apr 10.
4
Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression.血小板衍生生长因子-BB通过抑制miR-320的表达增强间充质干细胞介导的心脏保护作用。
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H980-9. doi: 10.1152/ajpheart.00737.2014. Epub 2015 Feb 27.
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Heart disease and stroke statistics--2015 update: a report from the American Heart Association.《2015年心脏病和中风统计数据更新：美国心脏协会报告》
Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152. Epub 2014 Dec 17.
6
Stem cell therapies in preclinical models of stroke associated with aging.衰老相关中风临床前模型中的干细胞疗法。
Front Cell Neurosci. 2014 Nov 3;8:347. doi: 10.3389/fncel.2014.00347. eCollection 2014.
7
Multimodal Approaches for Regenerative Stroke Therapies: Combination of Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is Not Superior to G-CSF Alone.多模态方法在再生性脑卒中治疗中的应用：粒细胞集落刺激因子联合骨髓间充质干细胞的效果并不优于粒细胞集落刺激因子单药治疗。
Front Aging Neurosci. 2014 Jun 23;6:130. doi: 10.3389/fnagi.2014.00130. eCollection 2014.
8
Cerebral neovascularization in diabetes: implications for stroke recovery and beyond.糖尿病中的脑血管新生：对卒中康复及其他方面的影响。
J Cereb Blood Flow Metab. 2014 Apr;34(4):553-63. doi: 10.1038/jcbfm.2014.18. Epub 2014 Feb 5.
9
Combination BMSC and Niaspan treatment of stroke enhances white matter remodeling and synaptic protein expression in diabetic rats.联合骨髓间充质干细胞和尼可占替诺治疗可增强糖尿病大鼠白质重塑和突触蛋白表达。
Int J Mol Sci. 2013 Nov 11;14(11):22221-32. doi: 10.3390/ijms141122221.
10
Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression.缺血神经元通过增加 VEGF 表达激活星形胶质细胞，破坏血管内皮屏障。
J Neurochem. 2014 Apr;129(1):120-9. doi: 10.1111/jnc.12611. Epub 2013 Dec 6.