Dooms-Goossens A, de Alam A G, Degreef H, Kochuyt A
Department of Medical Research (Dermatology), University Hospital, Katholieke Universiteit Leuven, Belgium.
Contact Dermatitis. 1989 Feb;20(2):124-6. doi: 10.1111/j.1600-0536.1989.tb03120.x.
The case of a 40-year-old woman with severe edema of the face and neck after the injection of a local dental anesthetic is presented. The reaction is attributed to the presence of sodium metabisulfite, and antioxidant, in the local anesthetic. Both the anesthetic and the sodium metabisulfite gave a delayed positive patch-test response.