Wilson Natalie M, Ripsch Matthew S, White Fletcher A
Loyola University Chicago, Maywood, IL 60153, USA.
Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pain Res Treat. 2016;2016:8364762. doi: 10.1155/2016/8364762. Epub 2016 Mar 16.
Aim. Nonsteroidal anti-inflammatory drugs or opioids are commonly used to control surgical pain following veterinary and clinical procedures. This study evaluated the efficacy of postoperative ketorolac or buprenorphine following abdominal surgery. Main Methods. Mean arterial pressure (MAP), heart rate, animal activity, corticosterone levels, and a nociceptive sensitivity assay were used to evaluate 18 adult male Sprague-Dawley rats which underwent aortic artery occlusion for implantation of a radiotelemetry device. The animals were treated postoperatively with intraperitoneal injections of vehicle, ketorolac (10 mg/kg), or buprenorphine (0.06 mg/kg) every 8 hours for 3 days. Key Findings. There were no consistent significant changes in any of the telemetry parameters after treatment with ketorolac compared with no saline treatment with the exception of increased MAP in the buprenorphine group during the first 48 hours when compared with other treatment groups. There was a sustained increase in fecal corticosterone levels from baseline on days 2-7 with buprenorphine compared with vehicle- or ketorolac-treated animals. All treatment conditions displayed reduced paw withdrawal thresholds (PWTs) from day 1 to day 21 following surgery. Compared with the vehicle treatment group, buprenorphine-treated animals exhibited significantly lower PWT levels from day 4 to 14 days. Significance. Given the prolonged increase in fecal corticosterone levels and pronounced changes in tactile hyperalgesia behavior in rodents subjected to buprenorphine treatment, these data suggest that ketorolac may be superior to buprenorphine for the treatment of postprocedure pain behavior in rodents.
目的。非甾体抗炎药或阿片类药物常用于控制兽医和临床手术后的疼痛。本研究评估了腹部手术后酮咯酸或丁丙诺啡的疗效。主要方法。使用平均动脉压（MAP）、心率、动物活动、皮质酮水平和伤害性敏感性测定法对18只成年雄性Sprague-Dawley大鼠进行评估，这些大鼠接受了主动脉动脉闭塞以植入无线电遥测装置。术后每8小时给动物腹腔注射溶媒、酮咯酸（10mg/kg）或丁丙诺啡（0.06mg/kg），持续3天。主要发现。与未用生理盐水治疗相比，用酮咯酸治疗后，遥测参数均无一致的显著变化，但与其他治疗组相比，丁丙诺啡组在最初48小时内MAP升高。与用溶媒或酮咯酸治疗的动物相比，丁丙诺啡组在术后第2 - 7天粪便皮质酮水平持续高于基线。所有治疗组在术后第1天至第21天爪子撤离阈值（PWTs）均降低。与溶媒治疗组相比，丁丙诺啡治疗的动物在第4天至第14天PWT水平显著更低。意义。鉴于丁丙诺啡治疗的啮齿动物粪便皮质酮水平持续升高以及触觉痛觉过敏行为有明显变化，这些数据表明，在治疗啮齿动物术后疼痛行为方面，酮咯酸可能优于丁丙诺啡。
