Verger Antoine, Hossu Gabriela, Kearney-Schwartz Anna, Bracard Serge, Roch Veronique, Van der Gucht Axel, Fay Renaud, Benetos Athanase, Marie Pierre-Yves, Joly Laure
Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Nancy, France.
Cerebrovasc Dis. 2016;42(1-2):106-9. doi: 10.1159/000445527. Epub 2016 Apr 13.
This study aimed at assessing the changes in brain metabolism related to white-matter magnetic resonance (MR) hyperintensities of presumed vascular origin, with a voxel-based quantitative analysis of (18F)-fluorodesoxyglucose positron emission tomography (FDG-PET) imaging.
Sixty older hypertensive patients with subjective memory complaints (75 ± 5 years, 34 women) were prospectively referred to FDG-PET and MRI brain imaging. The Statistical Parametric Mapping software was used to assess the correlation between brain distribution of FDG and white-matter hyperintensities assessed by the Fazekas score on MRI images.
The Fazekas score was inversely related to FDG uptake, independently of age and gender, within 14 Brodmann areas located mainly in the frontal lobe but also in certain limbic, insular and temporal areas. This relationship was also found to be largely independent of the volume of grey matter expressed in percentage of cranial volume, an index of atrophy.
White-matter MR hyperintensities of presumed vascular origin are cross-sectionally associated with a lower grey-matter metabolism, mainly but not only within frontal areas and independently of age, gender and grey-matter atrophy.
本研究旨在通过基于体素的（18F）-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）成像定量分析，评估与假定血管源性白质磁共振（MR）高信号相关的脑代谢变化。
前瞻性纳入60例有主观记忆主诉的老年高血压患者（75±5岁，34例女性），行FDG-PET和脑MRI检查。使用统计参数映射软件评估FDG脑分布与MRI图像上通过Fazekas评分评估的白质高信号之间的相关性。
在主要位于额叶但也包括某些边缘叶、岛叶和颞叶的14个Brodmann区域内，Fazekas评分与FDG摄取呈负相关，且独立于年龄和性别。还发现这种关系在很大程度上独立于以颅内容积百分比表示的灰质体积，即萎缩指数。
假定血管源性的白质MR高信号与较低的灰质代谢呈横断面相关，主要但不仅限于额叶区域，且独立于年龄、性别和灰质萎缩。
