Chen Di, Tang Shi-huan, Lu Peng, Yang Hong-jun
Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(21):4288-96.
The traditional Chinese medicine (TCM) theory of "treating heart and brain diseases with same methods (Nao Xin Tong Zhi: NXTZ)" has great significance to the treatment of cardiovascular and cerebrovascular diseases. It has been proven effective by a great deal of clinical researches. However, the underlying mechanism for this theory is still unclear. To provide insights into the potential mechanism of "NXTZ", this study attempts to deeply investigate the mechanism from two representative cardiovascular and cerebrovascular diseases, coronary heart disease (CHD) and cerebral apoplexy. First, various data resources were integrated to obtain different types of biomedical entities including drugs, targets, pathways and diseases. Then, three different approaches including text mining, biological network and enrichment analysis were utilized to recognize the potential common features between CHD and cerebral apoplexy, and the corresponding functions of drugs which could treat both diseases, thus unveiling the mechanism of NXTZ.
中医“脑心同治”理论对心脑血管疾病的治疗具有重要意义。大量临床研究已证明其有效性。然而，该理论的潜在机制仍不清楚。为深入了解“脑心同治”的潜在机制，本研究试图从两种具有代表性的心脑血管疾病——冠心病（CHD）和脑中风入手，深入探究其机制。首先，整合各种数据资源以获取不同类型的生物医学实体，包括药物、靶点、通路和疾病。然后，运用文本挖掘、生物网络和富集分析三种不同方法，识别冠心病和脑中风之间的潜在共同特征，以及可治疗这两种疾病的药物的相应功能，从而揭示“脑心同治”的机制。
