Deng Wei, Feng Xuebing, Li Xia, Wang Dandan, Sun Lingyun
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, PR China.
Cell Immunol. 2016 May;303:7-15. doi: 10.1016/j.cellimm.2016.04.001. Epub 2016 Apr 7.
Autoimmune disorders are a complicated and varied group of diseases arising from inappropriate immune responses. Recent studies have demonstrated that ongoing inflammatory and immune responses are associated with increased oxygen consumption, a process resulting in localized tissue hypoxia within inflammatory lesions ("inflammatory hypoxia"), in which hypoxia-inducible factor 1 (HIF-1), an oxygen-sensitive transcription factor that allows adaptation to hypoxia environments, has been shown to play an important function. HIF-1 is a regulator of angiogenesis and immune system. Besides, HIF-1-mediated metabolic shift and fibrosis may also play crucial roles in some autoimmune disorders. Firstly, we briefly summarize the role of HIF-1 in angiogenesis, immune responses and fibrosis. Secondly, we will show the major recent findings demonstrating a role for HIF-1 signaling in autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, systemic sclerosis and multiple sclerosis. The growing evidences may prompt HIF-1 to be a new target for treatment of autoimmune diseases.
自身免疫性疾病是一组由不适当免疫反应引起的复杂多样的疾病。最近的研究表明，持续的炎症和免疫反应与氧消耗增加有关，这一过程导致炎症病变内局部组织缺氧（“炎症性缺氧”），其中缺氧诱导因子1（HIF-1），一种允许适应缺氧环境的氧敏感转录因子，已被证明发挥重要作用。HIF-1是血管生成和免疫系统的调节因子。此外，HIF-1介导的代谢转变和纤维化在某些自身免疫性疾病中也可能起关键作用。首先，我们简要总结HIF-1在血管生成、免疫反应和纤维化中的作用。其次，我们将展示最近的主要研究结果，这些结果证明了HIF-1信号在自身免疫性疾病中的作用，包括类风湿性关节炎、炎症性肠病、银屑病、系统性硬化症和多发性硬化症。越来越多的证据可能促使HIF-1成为治疗自身免疫性疾病的新靶点。
