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微小RNA-183/182/96簇的高表达作为乳腺癌的一种预后生物标志物

High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer.

作者信息

Song Cailu, Zhang Lijuan, Wang Jin, Huang Zhongying, Li Xing, Wu Mingqing, Li Shuaijie, Tang Hailin, Xie Xiaoming

机构信息

Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Department of Nursing, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.

出版信息

Sci Rep. 2016 Apr 13;6:24502. doi: 10.1038/srep24502.

DOI:10.1038/srep24502
PMID:27071841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4829912/
Abstract

More sensitive and effective diagnostic markers for the detection of breast cancer are urgently needed. The microRNA-183/182/96 cluster has been reported to be involved in tumorigenesis and progression in a variety of cancers, and it is a promising cancer prognostic biomarker. The goal of this study was to determine the expression levels of the miR-183/182/96 cluster in breast cancer tissues and evaluate its prognostic role in breast cancer. Real-time quantitative polymerase chain reaction analysis (qRT-PCR) was used to detect the expression levels of the miR-183/182/96 cluster in 41 breast cancer tissues and adjacent normal tissues (control tissues) and also in different mammary cell lines. In situ hybridization (ISH) of the miR-183/182/96 cluster on 131 tissue microarrays (TMAs) was used to statistically analyze its prognostic role. The miR-183/182/96 cluster levels were significantly higher in breast cancer tissues than in control tissues. The miR-183/182/96 cluster was also upregulated in human breast cancer cell lines. An increased miR-183/182/96 cluster level was correlated with local relapse, distant metastasis and poor clinical outcomes. Our findings improve our understanding of the expression level of the miR-183/182/96 cluster in breast cancer and clarify the role of the miR-183/182/96 cluster as a novel prognostic biomarker for breast cancer.

摘要

迫切需要更灵敏、有效的乳腺癌诊断标志物。据报道，微小RNA-183/182/96簇参与多种癌症的肿瘤发生和进展，是一种很有前景的癌症预后生物标志物。本研究的目的是确定miR-183/182/96簇在乳腺癌组织中的表达水平，并评估其在乳腺癌中的预后作用。采用实时定量聚合酶链反应分析（qRT-PCR）检测41例乳腺癌组织及癌旁正常组织（对照组织）以及不同乳腺细胞系中miR-183/182/96簇的表达水平。对131个组织芯片（TMA）上的miR-183/182/96簇进行原位杂交（ISH），以统计分析其预后作用。乳腺癌组织中miR-183/182/96簇水平显著高于对照组织。miR-183/182/96簇在人乳腺癌细胞系中也上调。miR-183/182/96簇水平升高与局部复发、远处转移及不良临床结局相关。我们的研究结果增进了我们对miR-183/182/96簇在乳腺癌中表达水平的理解，并阐明了miR-183/182/96簇作为乳腺癌新型预后生物标志物的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/385d137c06aa/srep24502-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/50c1c7d501d1/srep24502-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/51e04689e307/srep24502-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/385d137c06aa/srep24502-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/50c1c7d501d1/srep24502-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/51e04689e307/srep24502-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/4829912/385d137c06aa/srep24502-f3.jpg

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