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2007年和2013年养老院认知障碍患者的行为和心理症状及精神药物

Behavioral and psychological symptoms and psychotropic drugs among people with cognitive impairment in nursing homes in 2007 and 2013.

作者信息

Gustafsson Maria, Isaksson Ulf, Karlsson Stig, Sandman Per-Olof, Lövheim Hugo

机构信息

Department of Pharmacology and Clinical Neuroscience, Division of Clinical Pharmacology, Umeå University, 901 87, Umeå, Sweden.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, 901 87, Umeå, Sweden.

出版信息

Eur J Clin Pharmacol. 2016 Aug;72(8):987-94. doi: 10.1007/s00228-016-2058-5. Epub 2016 Apr 13.

Abstract

PURPOSE

The use of psychotropic drugs to treat behavioral and psychological symptoms among people with dementia has been widely questioned because of its limited efficacy and risk of harmful side-effects. The objectives of this study was to compare the prevalence of behavioral and psychological symptoms and the use of psychotropic drug treatments among old people with cognitive impairment living in geriatric care units in 2007 and 2013.

METHODS

Two questionnaire surveys were performed in 2007 and 2013, comprising all those living in geriatric care units in the county of Västerbotten in northern Sweden. A comparison was made between 1971 people from 2007 and 1511 people from 2013. Data were collected concerning psychotropic and antidementia drug use, functioning in the activities of daily living (ADL), cognition, and behavioral and psychological symptoms, using the Multi-Dimensional Dementia Assessment Scale (MDDAS).

RESULTS

Between 2007 and 2013, the use of antipsychotic drugs declined from 25.4 to 18.9 %, and of anxiolytic, hypnotic, and sedative drugs from 35.5 to 29.4 %. The prevalence of people prescribed antidepressant drugs remained unchanged while antidementia drug prescription increased from 17.9 to 21.5 %. When controlled for demographic changes, 36 out of 39 behavioral and psychological symptoms showed no difference in prevalence between the years.

CONCLUSIONS

The use of antipsychotic, anxiolytic, hypnotic, and sedative drugs declined considerably between 2007 and 2013 among old people with cognitive impairment living in geriatric care units. Despite this reduction, the prevalences of behavioral and psychological symptoms remained largely unchanged.

摘要

目的

由于疗效有限且存在有害副作用风险,使用精神药物治疗痴呆患者的行为和心理症状受到广泛质疑。本研究的目的是比较2007年和2013年居住在老年护理机构中的认知障碍老年人的行为和心理症状患病率以及精神药物治疗的使用情况。

方法

分别于2007年和2013年进行了两次问卷调查,涵盖瑞典北部韦斯特博滕县老年护理机构中的所有居民。对2007年的1971人和2013年的1511人进行了比较。使用多维度痴呆评估量表(MDDAS)收集了有关精神药物和抗痴呆药物使用、日常生活活动(ADL)功能、认知以及行为和心理症状的数据。

结果

2007年至2013年期间,抗精神病药物的使用从25.4%降至18.9%,抗焦虑、催眠和镇静药物的使用从35.5%降至29.4%。开具抗抑郁药物的人群患病率保持不变,而抗痴呆药物处方从17.9%增加到21.5%。在控制人口统计学变化后,39种行为和心理症状中有36种在这几年间患病率没有差异。

结论

2007年至2013年期间,居住在老年护理机构中的认知障碍老年人使用抗精神病、抗焦虑、催眠和镇静药物的情况大幅下降。尽管有这种减少,但行为和心理症状的患病率基本保持不变。

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