Aich Ranen Kanti, Mondal Nirmal Kumar, Chhatui Bappaditya, Sepai Harris Mahammad, Aich Rajarshi, Acharyya Amitava, Manir Kaji, Bhattacharaya Jibak
Department of Radiotherapy, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
J Cancer Res Ther. 2016 Jan-Mar;12(1):302-8. doi: 10.4103/0973-1482.160929.
Incidence of breast cancer is on the rise in developed as well as in developing countries. In India it has superseded cervical cancer as the commonest malignancy in women in urban areas. A lot of risk factors have been proposed from time to time that play a causative role in the natural course of this disease. However, they are based on data accumulated from studies conducted mostly in developed countries. Aim of this study was to find out whether these known and/or presumptive breast cancer risk factors hold true for women of developing countries like India also.
From 2008 to 2012; 1,463 breast cancer patients were compared side by side with 1,440 matched controls by predetermined questionnaire and anthropometric variables. Data were analyzed by Statistical Package for Social Sciences (SPSS) V19 software todetermine whether selected risk factors were more common in the patient group than the control group.
The risk factors under study were also found to be statistically significant for the study populationexcept duration of breastfeeding and family history of breast and ovarian cancers.
Risk factors for breast cancer do not differ significantly between developed and developing countries. Hence appropriate time has come for developing countries to incorporate breast cancer risk factors in health education and to consider pharmacological interventions in high risk women.
发达国家和发展中国家的乳腺癌发病率均呈上升趋势。在印度,它已取代宫颈癌,成为城市地区女性最常见的恶性肿瘤。人们不时提出许多风险因素,它们在这种疾病的自然病程中起致病作用。然而,这些因素是基于大多在发达国家进行的研究积累的数据。本研究的目的是查明这些已知和/或推定的乳腺癌风险因素对像印度这样的发展中国家的女性是否也适用。
2008年至2012年期间,通过预先确定的问卷和人体测量变量,将1463例乳腺癌患者与1440例匹配的对照进行了并列比较。数据使用社会科学统计软件包(SPSS)V19软件进行分析,以确定所选风险因素在患者组中是否比对照组更常见。
除母乳喂养时间以及乳腺癌和卵巢癌家族史外,所研究的风险因素在研究人群中也具有统计学意义。
发达国家和发展中国家的乳腺癌风险因素没有显著差异。因此,发展中国家已到了将乳腺癌风险因素纳入健康教育并考虑对高危女性进行药物干预的时候了。