Li Yong-Feng, Liu Zhi-Qiang, Zhang Yu-Shun, Dong Li-Ming, Wang Chun-You, Gou Shan-Miao, Wu He-Shui
Pancreatic Disease Institute, Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2016 Apr;36(2):205-210. doi: 10.1007/s11596-016-1567-x. Epub 2016 Apr 13.
Locally advanced pancreatic cancer is associated with a very poor prognosis. This study was performed to evaluate whether patients with locally advanced pancreatic cancer benefit from (125)I seed implantation. This retrospective study included 224 patients with locally advanced pancreatic cancer, with 137 patients (61.2%) in the implantation (IP) group and 87 (38.9%) in the non-implantation (NIP) group. The survival status, complications and objective curative effects were compared between the groups. The average operative time in the IP group was significantly longer than that in the NIP group (243±51 vs. 214±77 min). The tumor response rates were 9.5% and 0 at the 2nd month after surgery in the IP and NIP groups, respectively (P<0.05). The IP group exhibited a trend toward pain relief at the 6th month after surgery. The global health status scores of the IP group were higher than those of the NIP group at the 3rd and 6th month after surgery. The median survival time in the IP group was significantly longer than that in the NIP group. In conclusion, patients with locally advanced pancreatic cancer can benefit from (125)I seed implantation in terms of local tumor control, survival time, pain relief and quality of life.
局部晚期胰腺癌的预后非常差。本研究旨在评估局部晚期胰腺癌患者是否能从碘-125粒子植入中获益。这项回顾性研究纳入了224例局部晚期胰腺癌患者，其中137例（61.2%）为植入组（IP组），87例（38.9%）为非植入组（NIP组）。比较两组患者的生存状况、并发症及客观疗效。IP组的平均手术时间显著长于NIP组（243±51分钟 vs. 214±77分钟）。术后第2个月，IP组和NIP组的肿瘤缓解率分别为9.5%和0（P<0.05）。IP组在术后第6个月有疼痛缓解的趋势。术后第3个月和第6个月，IP组的总体健康状况评分高于NIP组。IP组的中位生存时间显著长于NIP组。总之，局部晚期胰腺癌患者在局部肿瘤控制、生存时间、疼痛缓解和生活质量方面可从碘-125粒子植入中获益。
