Stricker-Krongrad Alain, Shoemake Catherine R, Bouchard Guy F
Sinclair Research Center, Columbia, Missouri, USA.
Sinclair Research Center, Columbia, Missouri, USA
Toxicol Pathol. 2016 Jun;44(4):612-23. doi: 10.1177/0192623316641784. Epub 2016 Apr 12.
The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are regularly used for studies designed to assess efficacy and safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to rodents, canines, or nonhuman primates. Translational preclinical swine study data presented here support the current understanding that miniature swine are the animal model of choice for the assessment of drugs targeting endocrine, dermal, and ocular disorders. Because research investigators need to be familiar with some of the important features of the models developed in the miniature swine in order to place clinical and experimental findings in their proper perspective, relevant references and data from these models will be presented, compared, and partially illustrated.
在过去十多年里，小型猪作为一种非啮齿类动物在研究中的应用持续扩大，它们在实验药理学以及作为人类疾病的治疗模型方面正得到常规使用。小型猪模型经常用于旨在评估通过不同给药途径给予的新治疗化合物的疗效和安全性的研究，并被用作啮齿动物、犬类或非人灵长类动物的替代模型。此处呈现的转化性临床前猪研究数据支持了当前的认识，即小型猪是评估针对内分泌、皮肤和眼部疾病药物的首选动物模型。由于研究人员需要熟悉在小型猪中建立的模型的一些重要特征，以便正确看待临床和实验结果，因此将展示、比较并部分说明这些模型的相关参考文献和数据。
