Shrader Stephanie M, Greentree William F
1 Charles River Laboratories, Spencerville, Ohio, USA.
Toxicol Pathol. 2018 Jun;46(4):403-407. doi: 10.1177/0192623318770379. Epub 2018 Apr 22.
Since their development in the 1960s, Göttingen minipigs have become a popular nonrodent animal model in biomedical research, especially for ocular studies, because of their ease of handling, size, well-monitored genetics, and ocular anatomy that is similar to humans. The purpose of this mini-review is to introduce the reader to the various ways in which this animal model is currently being utilized in ocular research and to provide an overview of the diagnostic modalities that aid in this research. To date, the Göttingen minipig has been used for a variety of ocular research endeavors, including studies evaluating the safety and efficacy of ocular therapeutics, glaucoma etiopathogenesis and treatment, novel biomaterials, surgical procedures, and implantable materials/devices. In addition to histopathologic evaluation of enucleated globes, the majority of these studies make use of advanced in vivo diagnostic techniques, including electroretinography, optical coherence tomography, fundoscopic imaging, and fluorescein angiography.
自20世纪60年代培育以来，哥廷根小型猪已成为生物医学研究中一种受欢迎的非啮齿动物模型，特别是在眼科研究中，因为它们易于处理、体型合适、遗传得到良好监测，且眼部解剖结构与人类相似。本小型综述的目的是向读者介绍这种动物模型目前在眼科研究中的各种应用方式，并概述有助于该研究的诊断方法。迄今为止，哥廷根小型猪已被用于各种眼科研究工作，包括评估眼科治疗药物的安全性和有效性、青光眼的病因发病机制和治疗、新型生物材料、手术程序以及可植入材料/装置的研究。除了对摘除眼球进行组织病理学评估外，这些研究大多还利用了先进的体内诊断技术，包括视网膜电图、光学相干断层扫描、眼底成像和荧光素血管造影。
