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韦格纳肉芽肿病的临床病理特征：三例报告

Clinicopathologic characteristics of Weneger's granulomatosis: A report of three cases.

作者信息

Gao Li-Yong, Ding Jin, Zhao L I

机构信息

Department of Pathology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China.

出版信息

Exp Ther Med. 2016 Apr;11(4):1340-1344. doi: 10.3892/etm.2016.3046. Epub 2016 Feb 3.

DOI:10.3892/etm.2016.3046
PMID:27073446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4812588/
Abstract

Weneger's granulomatosis (WG) is a rare autoimmune disease affecting a number of organs, including lungs and kidney. Although all age groups may be affected, the peak incidence occurs for individuals aged 30-50 years, with a slightly increased prevalence in males. In the current study, we present three cases of WG to describe clinical and pathological characteristics of this disease. Three patients with WG were assessed for clinical and pathological characteristics, and typical morphological findings using computerized tomography. Clinical manifestations included vasculitis, tissue necrosis, and the formation of granuloma. Following a large dose of glucocorticoid hormone treatment, the symptoms were successfully relieved in all three patients. In conclusion, the diagnosis of WG is dependent on pathological examination in combination with appropriate clinical and imaging data, and immunostaining with anti-neutrophil cytoplasmic antibody.

摘要

韦格纳肉芽肿（WG）是一种罕见的自身免疫性疾病，可累及多个器官，包括肺和肾。虽然所有年龄组均可受累，但发病高峰出现在30至50岁的个体，男性患病率略有增加。在本研究中，我们报告3例WG病例以描述该疾病的临床和病理特征。对3例WG患者进行了临床和病理特征评估，并使用计算机断层扫描观察典型的形态学表现。临床表现包括血管炎、组织坏死和肉芽肿形成。经过大剂量糖皮质激素治疗，所有3例患者的症状均成功缓解。总之，WG的诊断依赖于病理检查，并结合适当的临床和影像学数据，以及抗中性粒细胞胞浆抗体免疫染色。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/d303d1323700/etm-11-04-1340-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/e2299b7b066a/etm-11-04-1340-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/140faf963162/etm-11-04-1340-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/08b245e9f724/etm-11-04-1340-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/28c8bbbaeaf1/etm-11-04-1340-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/ff482842b029/etm-11-04-1340-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/def8c6e776cb/etm-11-04-1340-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/50dab5e4d229/etm-11-04-1340-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/fed628771dd1/etm-11-04-1340-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/d303d1323700/etm-11-04-1340-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/e2299b7b066a/etm-11-04-1340-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/140faf963162/etm-11-04-1340-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/08b245e9f724/etm-11-04-1340-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/28c8bbbaeaf1/etm-11-04-1340-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/ff482842b029/etm-11-04-1340-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/def8c6e776cb/etm-11-04-1340-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/50dab5e4d229/etm-11-04-1340-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/fed628771dd1/etm-11-04-1340-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9db9/4812588/d303d1323700/etm-11-04-1340-g08.jpg

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