通过层层自组装制备新型复合纳米纤维凝胶包封的人胎盘提取物。
Preparation of a novel composite nanofiber gel-encapsulated human placental extract through layer-by-layer self-assembly.
作者信息
Liu Guohui, Chen X I, Zhou W U, Yang Shuhua, Ye Shunan, Cao Faqi, Liu Y I, Xiong Yuan
机构信息
Department of Orthopedics, Union Hospital, Tongi Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
出版信息
Exp Ther Med. 2016 Apr;11(4):1447-1452. doi: 10.3892/etm.2016.3084. Epub 2016 Feb 17.
Aqueous human placenta extract (HPE) has been previously used to treat chronic soft tissue ulcer; however, the optimal dosage of HPE has yet to be elucidated. The present study investigated a novel nanofiber gel composed through layer-by-layer (LbL) self-assembly, in which HPE was encapsulated. IKVAV, RGD, RAD16 and FGL-PA were screened and combined to produce an optimal vehicle nanofiber gel through LbL assembly. Subsequently, the aqueous HPE was encapsulated into this nanofiber at the appropriate concentration, and the morphology, particle size, drug loading efficacy, encapsulation rate, release efficiency and structure validation were detected. The encapsulation efficiency of all three HPE samples was >90%, the nanofiber gel exhibited a slow releasing profile, and the structure of HPE encapsulated in the nanofiber gel was unvaried. In conclusion, this type of novel composite nanocapsules may offer a promising delivery system for HPE.
人胎盘水提取物（HPE）此前已被用于治疗慢性软组织溃疡；然而，HPE的最佳剂量尚未阐明。本研究调查了一种通过层层（LbL）自组装构成的新型纳米纤维凝胶，其中包封了HPE。筛选并组合了IKVAV、RGD、RAD16和FGL-PA，通过LbL组装制备出最佳的载体纳米纤维凝胶。随后，将水相HPE以适当浓度包封到该纳米纤维中，并检测其形态、粒径、载药效率、包封率、释放效率和结构验证。所有三种HPE样品的包封效率均>90%，纳米纤维凝胶呈现出缓释曲线，且包封在纳米纤维凝胶中的HPE结构未发生变化。总之，这种新型复合纳米胶囊可能为HPE提供一种有前景的递送系统。
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