• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature.与SET-NUP214重排相关的B细胞急性淋巴细胞白血病：一例报告并文献复习
Oncol Lett. 2016 Apr;11(4):2644-2650. doi: 10.3892/ol.2016.4260. Epub 2016 Feb 23.
2
The characteristics and prognostic significance of the SET-CAN/NUP214 fusion gene in hematological malignancies: A systematic review.SET-CAN/NUP214 融合基因在血液系统恶性肿瘤中的特征及预后意义：系统评价。
Medicine (Baltimore). 2022 Jul 29;101(30):e29294. doi: 10.1097/MD.0000000000029294.
3
A Case of Acute Myeloid Leukemia with Myelodysplasia-Related Changes, SET-NUP214 Fusion, and Complex Karyotype.1例伴有骨髓发育异常相关改变、SET-NUP214融合及复杂核型的急性髓系白血病
Clin Lab. 2022 Dec 1;68(12). doi: 10.7754/Clin.Lab.2022.220313.
4
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines.急性髓系白血病和 T 细胞急性淋巴细胞白血病源性细胞系中的 SET-NUP214 融合。
J Hematol Oncol. 2009 Jan 23;2:3. doi: 10.1186/1756-8722-2-3.
5
A novel variant translocation (1;9)(p22;q34) resulting in a DEK/NUP214 fusion gene in a patient with acute myeloid leukemia: A case report.一名急性髓系白血病患者中出现导致DEK/NUP214融合基因的新型变异易位(1;9)(p22;q34)：病例报告
Oncol Lett. 2017 Dec;14(6):7021-7024. doi: 10.3892/ol.2017.7133. Epub 2017 Oct 3.
6
T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature.伴有复杂核型和SET-NUP214重排的T细胞急性淋巴细胞白血病：病例报告及文献复习
Ann Clin Lab Sci. 2011 Summer;41(3):267-72.
7
[Expression of SET-NUP214 fusion gene in patients with T-cell acute lymphoblastic leukemia and its clinical significance].[SET-NUP214融合基因在T细胞急性淋巴细胞白血病患者中的表达及其临床意义]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1047-51.
8
SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances.白血病中的SET-CAN/NUP214融合基因：一般特征与临床进展
Front Oncol. 2023 Oct 16;13:1269531. doi: 10.3389/fonc.2023.1269531. eCollection 2023.
9
[Analysis of the clinical characteristics of 24 cases of hematological malignancies with SET-NUP214 fusion gene].24例伴有SET-NUP214融合基因的血液系统恶性肿瘤临床特征分析
Zhonghua Xue Ye Xue Za Zhi. 2021 Jun 14;42(6):459-465. doi: 10.3760/cma.j.issn.0253-2727.2021.06.004.
10
Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement.伴有 del(9)(q34);SET-NUP214 重排的成人 T 细胞急性淋巴细胞白血病的表型和遗传学特征。
Ann Hematol. 2012 Feb;91(2):193-201. doi: 10.1007/s00277-011-1289-x. Epub 2011 Jul 1.

引用本文的文献

1
fusion genes in acute leukemias: genetic characterization of rare cases.急性白血病中的融合基因：罕见病例的遗传学特征
Front Oncol. 2024 Mar 20;14:1371980. doi: 10.3389/fonc.2024.1371980. eCollection 2024.
2
SET-CAN/NUP214 fusion gene in leukemia: general features and clinical advances.白血病中的SET-CAN/NUP214融合基因：一般特征与临床进展
Front Oncol. 2023 Oct 16;13:1269531. doi: 10.3389/fonc.2023.1269531. eCollection 2023.
3
[Analysis of the clinical characteristics of 24 cases of hematological malignancies with SET-NUP214 fusion gene].24例伴有SET-NUP214融合基因的血液系统恶性肿瘤临床特征分析
Zhonghua Xue Ye Xue Za Zhi. 2021 Jun 14;42(6):459-465. doi: 10.3760/cma.j.issn.0253-2727.2021.06.004.
4
Interstitial Deletions Generating Fusion Genes.形成融合基因的染色体间片段缺失
Cancer Genomics Proteomics. 2021 May-Jun;18(3):167-196. doi: 10.21873/cgp.20251.
5
Determining the Appropriate Treatment for T-Cell Acute Lymphoblastic Leukemia With Fusion: Perspectives From a Case Report and Literature Review.确定伴有融合的T细胞急性淋巴细胞白血病的适当治疗方法：来自一例病例报告及文献综述的观点
Front Oncol. 2021 Mar 26;11:651494. doi: 10.3389/fonc.2021.651494. eCollection 2021.
6
Prognostic significance of SET-NUP214 fusion gene in acute leukemia after allogeneic hematopoietic stem cell transplantation.SET-NUP214 融合基因在异基因造血干细胞移植后急性白血病中的预后意义。
Medicine (Baltimore). 2020 Dec 11;99(50):e23569. doi: 10.1097/MD.0000000000023569.
7
Fusion Gene in Acute Leukemia and Myeloid Neoplasms: Report of Three Cases and a Literature Review.急性白血病和髓系肿瘤中的融合基因：三例报告及文献综述
Onco Targets Ther. 2020 Aug 3;13:7665-7681. doi: 10.2147/OTT.S258365. eCollection 2020.
8
Genetic Signature of Acute Lymphoblastic Leukemia and Netherton Syndrome Co-incidence-First Report in the Literature.急性淋巴细胞白血病与 Netherton 综合征共现的基因特征——文献中的首例报告
Front Oncol. 2020 Jan 17;9:1477. doi: 10.3389/fonc.2019.01477. eCollection 2019.
9
A Rare Case of Acute Myeloid Leukemia With Fusion and Massive Hyperdiploidy.一例罕见的伴有融合及大量超二倍体的急性髓系白血病
Ann Lab Med. 2019 Jul;39(4):403-405. doi: 10.3343/alm.2019.39.4.403.
10
NUP214 in Leukemia: It's More than Transport.NUP214 在白血病中的作用：不止是运输。
Cells. 2019 Jan 21;8(1):76. doi: 10.3390/cells8010076.

本文引用的文献

1
SET-NUP214 is a recurrent γδ lineage-specific fusion transcript associated with corticosteroid/chemotherapy resistance in adult T-ALL.SET-NUP214 是一种与成人 T 细胞 ALL 中糖皮质激素/化疗耐药相关的、反复出现的 γδ 谱系特异性融合转录本。
Blood. 2014 Mar 20;123(12):1860-3. doi: 10.1182/blood-2013-08-521518. Epub 2014 Jan 21.
2
Detection and clinical significance of gene rearrangements in Chinese patients with adult acute lymphoblastic leukemia.检测中国成人急性淋巴细胞白血病患者中的基因重排及其临床意义。
Leuk Lymphoma. 2013 Jul;54(7):1521-6. doi: 10.3109/10428194.2012.754888. Epub 2013 Jan 7.
3
[Expression of SET-NUP214 fusion gene in patients with T-cell acute lymphoblastic leukemia and its clinical significance].[SET-NUP214融合基因在T细胞急性淋巴细胞白血病患者中的表达及其临床意义]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1047-51.
4
[Gene rearrangement pattern of immunoglobulin and T-cell receptor (Ig/TR) and its clinical characteristics in children with SET-NUP214 fusion gene-positive leukemia/lymphoma].[SET-NUP214融合基因阳性白血病/淋巴瘤患儿免疫球蛋白和T细胞受体（Ig/TR）基因重排模式及其临床特征]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Dec;19(6):1362-7.
5
Detection of SET-NUP214 rearrangement using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) in acute leukemias: a case report and literature review on a Korean case series.利用多重逆转录聚合酶链反应（RT-PCR）检测急性白血病中的SET-NUP214重排：1例韩国病例报告及文献复习
Ann Hematol. 2012 Jul;91(7):1135-8. doi: 10.1007/s00277-011-1366-1. Epub 2011 Nov 19.
6
T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature.伴有复杂核型和SET-NUP214重排的T细胞急性淋巴细胞白血病：病例报告及文献复习
Ann Clin Lab Sci. 2011 Summer;41(3):267-72.
7
Diagnostic standardization of leukemia fusion gene detection system using multiplex reverse transcriptase-polymerase chain reaction in Korea.韩国利用多重逆转录聚合酶链反应对白血病融合基因检测系统进行诊断标准化
J Korean Med Sci. 2011 Oct;26(10):1399-400; author reply 1401. doi: 10.3346/jkms.2011.26.10.1399. Epub 2011 Oct 1.
8
Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.PHF6 突变与 T 细胞急性淋巴细胞白血病中的 NOTCH1、JAK1 突变和 SET-NUP214 重排相关。
Haematologica. 2011 Dec;96(12):1808-14. doi: 10.3324/haematol.2011.043083. Epub 2011 Aug 31.
9
Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement.伴有 del(9)(q34);SET-NUP214 重排的成人 T 细胞急性淋巴细胞白血病的表型和遗传学特征。
Ann Hematol. 2012 Feb;91(2):193-201. doi: 10.1007/s00277-011-1289-x. Epub 2011 Jul 1.
10
Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia.一例急性未分化白血病中SET-NUP214可变融合转录本的分子特征分析
Cancer Genet Cytogenet. 2010 Sep;201(2):73-80. doi: 10.1016/j.cancergencyto.2010.05.010.

与SET-NUP214重排相关的B细胞急性淋巴细胞白血病：一例报告并文献复习

B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature.

作者信息

Zhu Hong-Hu, Zhao Xiao-Su, Qin Ya-Zhen, Lai Yue-Yun, Jiang Hao

机构信息

Department of Hematology, Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, P.R. China.

出版信息

Oncol Lett. 2016 Apr;11(4):2644-2650. doi: 10.3892/ol.2016.4260. Epub 2016 Feb 23.

DOI:10.3892/ol.2016.4260
PMID:27073532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4812124/
Abstract

The SET nuclear proto-oncogene (SET)-nucleoporin (NUP)214 fusion gene, which results from cryptic t(9;9)(q34;q34) or del(9)(q34.11q34.13), is a rare genetic event in hematological malignancies. The majority of patients carrying SET-NUP214 experience T-cell acute lymphoblastic leukemia (T-ALL), but rarely experience acute undifferentiated leukemia or acute myeloid leukemia. The current study presents the case of a 19-year-old male patient with B-cell ALL (B-ALL) carrying the SET-NUP214 fusion gene, in addition to an fms-related tyrosine kinase 3-internal tandem duplication mutation and a complex karyotype abnormality. The patient exhibited chemotherapy resistance. To the best of our knowledge, the present study is the first report of a case of B-ALL carrying the SET-NUP214 fusion gene, and provides a review of the literature.

摘要

SET核原癌基因（SET）-核孔蛋白（NUP）214融合基因由隐匿性t（9；9）（q34；q34）或del（9）（q34.11q34.13）产生，是血液系统恶性肿瘤中一种罕见的基因事件。大多数携带SET-NUP214的患者罹患T细胞急性淋巴细胞白血病（T-ALL），但很少罹患急性未分化白血病或急性髓系白血病。本研究报告了一例19岁男性B细胞急性淋巴细胞白血病（B-ALL）患者，其携带SET-NUP214融合基因，同时伴有fms相关酪氨酸激酶3内部串联重复突变和复杂的核型异常。该患者表现出化疗耐药性。据我们所知，本研究是首例关于携带SET-NUP214融合基因的B-ALL病例报告，并提供了文献综述。