Philadelphia chromosome-negative non-Hodgkin's lymphoma occurring in Philadelphia chromosome-positive chronic myeloid leukemia: A case report and literature review.

The current study reports the case of a patient with Philadelphia chromosome-negative (Ph) non-Hodgkin's lymphoma (NHL) and chronic phase (CP) Philadelphia chromosome-positive (Ph) chronic myeloid leukemia (CML) that also possessed characteristic enlarged lymph nodes. A lymph node biopsy resulted in the diagnosis of CP-CML, in addition to T-lymphoblastic cell NHL with negative break point cluster/Abelson tyrosine kinase fusion genes in the lymph node of the patient, which was diagnosed as Ph NHL. A review of the literature was performed in the present study to investigate the genetic differences between Ph NHL and Ph NHL in patients with CML. The median age of patients with NHL and CML was 41 years. The follow-up time of patients with Ph NHL was significantly shorter (mean, <6 months) compared to the follow-up time of patients with Ph NHL (mean, >15 months). Therefore the present study concludes that Ph NHL may be more aggressive compared with Ph NHL. The present study suggests that additional studies are required to assess the clinical and genetic characteristics of NHL patients with CML.