Daragmeh Jamila, Barriah Waseim, Saad Bashar, Zaid Hilal
Faculty of Arts and Sciences, The Arab American University - Jenin, Jenin 11184, Palestine.
Qasemi Research Center, Al-Qasemi Academic College of Education, Baqa El-Gharbia 30100, Israel.
Oncol Lett. 2016 Apr;11(4):2913-2918. doi: 10.3892/ol.2016.4309. Epub 2016 Mar 8.
Recent advances in genomics, proteomics, cell biology and biochemistry of tumors have revealed new pathways that are aberrantly activated in numerous cancer types. However, the enormous amount of data available in this field may mislead scientists in focused research. As cancer cell growth and progression is often dependent upon the phosphoinositide 3-kinase (PI3K)/AKT pathway, there has been extensive research into the proteins implicated in the PI3K pathway. Using data available in the Human Protein Atlas database, the current study investigated the expression of 25 key proteins that are known to be involved with PI3K pathway activation in a distinct group of 20 cancer types. These proteins are AKTIP, ARP1, BAD, GSK3A, GSK3B, MERTK-1, PIK3CA, PRR5, PSTPIP2, PTEN, FOX1, RHEB, RPS6KB1, TSC1, TP53, BCL2, CCND1, WFIKKN2, CREBBP, caspase-9, PTK2, EGFR, FAS, CDKN1A and XIAP. The analysis revealed pronounced expression of specific proteins in distinct cancer tissues, which may have the potential to serve as targets for treatments and provide insights into the molecular basis of cancer.
肿瘤基因组学、蛋白质组学、细胞生物学和生物化学领域的最新进展揭示了在多种癌症类型中异常激活的新途径。然而，该领域现有的大量数据可能会误导科学家进行有针对性的研究。由于癌细胞的生长和进展通常依赖于磷酸肌醇3激酶（PI3K）/AKT途径，因此对PI3K途径中涉及的蛋白质进行了广泛研究。利用人类蛋白质图谱数据库中的现有数据，本研究调查了已知参与20种不同癌症类型PI3K途径激活的25种关键蛋白质的表达情况。这些蛋白质包括AKTIP、ARP1、BAD、GSK3A、GSK3B、MERTK-1、PIK3CA、PRR5、PSTPIP2、PTEN、FOX1、RHEB、RPS6KB1、TSC1、TP53、BCL2、CCND1、WFIKKN2、CREBBP、caspase-9、PTK2、EGFR、FAS、CDKN1A和XIAP。分析揭示了特定蛋白质在不同癌症组织中的显著表达，这可能有潜力作为治疗靶点，并为癌症的分子基础提供见解。
