Goren A I, Bruderman I
Research Institute for Environmental Health Ministry of Health and Sackler School of Medicine, Tel Aviv, Israel.
Eur J Epidemiol. 1989 Mar;5(1):58-64. doi: 10.1007/BF00145046.
A panel of 377 healthy adults and 920 COPD patients aged 30-65 years, is annually interviewed (ATS-NHLI health questionnaire) and performs pulmonary function test (PFT), which includes: FVC, FEV1, FEV1/FVC, PEF, FEF50 and FEF75. Baseline data analysis showed a more significant excess in respiratory symptoms (8.8% to 21.4%) and lower PFT (2.4% to 8.0%) among patients occupationally exposed to dust, than among healthy exposed panelists (-0.7% to 7.7% excess symptomatology and -0.3 to 5.8% lower PFT). Among patients a significant correlation between PFT and degree of occupational dust exposure was found. Significantly lower FEV1/FVC and excess in respiratory symptoms (with relative risks of 2.47-16.38) was present in healthy smokers vs. non smokers as compared with COPD patients.
一组由377名30至65岁的健康成年人和920名慢性阻塞性肺疾病（COPD）患者组成的样本，每年接受访谈（采用美国胸科学会-美国国立心肺血液研究所健康问卷）并进行肺功能测试（PFT），该测试包括：用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、FEV1/FVC、呼气峰值流速（PEF）、50%用力呼气流量（FEF50）和75%用力呼气流量（FEF75）。基线数据分析显示，职业性接触粉尘的患者中，呼吸道症状的超标情况（8.8%至21.4%）和肺功能测试结果较低（2.4%至8.0%）比健康的接触组参与者更为显著（症状超标-0.7%至7.7%，肺功能测试结果降低-0.3%至5.8%）。在患者中，发现肺功能测试与职业性粉尘接触程度之间存在显著相关性。与慢性阻塞性肺疾病患者相比，健康吸烟者的FEV1/FVC显著降低，呼吸道症状超标（相对风险为2.47至16.38）。
