Sosunov E A, Balashov V P, Kostin Ia V, Gendenshteĭn E I
Farmakol Toksikol. 1989 Jan-Feb;52(1):42-3.
The conventional microelectrode technique was used to study the effects of trimecaine and its quaternary derivative G-103 on the action potential in the rat myocardium. G-103 suppressed the maximal rate of the action potential depolarization at lower concentrations than trimecaine although its effect developed slower: t 1/2 = 25 and 5 min, respectively. G-103 abolished the tonic component of trimecaine-induced blockade and failed to alter the rate-dependent component.
采用传统微电极技术研究了三甲卡因及其季铵衍生物G-103对大鼠心肌动作电位的影响。G-103在比三甲卡因更低的浓度下就能抑制动作电位去极化的最大速率，尽管其作用起效较慢：t1/2分别为25分钟和5分钟。G-103消除了三甲卡因诱导的阻滞的强直成分，且未能改变速率依赖性成分。
