Kliment'eva T K, Sal'nik B Iu, Chamina G M
Farmakol Toksikol. 1989 Jan-Feb;52(1):71-4.
Antitumour drugs prospidine and spirobromine were shown to suppress the activity of the mouse liver lysosome enzymes in vivo and in experiments in vitro. The revealed effect was underlied by a decrease of lysosomal membrane permeability for the corresponding substrates and enzymes rather than a reduction of the catalytic activity of acid hydrolases.
抗肿瘤药物丙胺亚胺和螺溴铵在体内和体外实验中均显示出可抑制小鼠肝脏溶酶体酶的活性。所揭示的这种效应的基础是溶酶体膜对相应底物和酶的通透性降低，而非酸性水解酶催化活性的降低。
