Batte Anthony, Lwabi Peter, Lubega Sulaiman, Kiguli Sarah, Nabatte Violette, Karamagi Charles
Child Health and Development Centre, Makerere University College of Health Sciences, P.O Box 6717, Kampala, Uganda.
Uganda Heart Institute, P.O. Box 7051, Kampala, Uganda.
BMC Cardiovasc Disord. 2016 Apr 13;16:67. doi: 10.1186/s12872-016-0243-1.
In Uganda, few children with congenital heart diseases (CHD) benefit from early corrective cardiac surgery. These children are at high risk of developing heart failure and electrolyte imbalances; factors which increase their risk of developing arrhythmias. This study aimed to determine the prevalence and factors associated with arrhythmias among children with congenital heart diseases receiving care at Mulago Hospital.
This was a cross-sectional study carried out from August 2013 to March 2014 at Mulago Hospital. Children were consecutively enrolled into the study. Standard 12-lead electrocardiograms (ECGs) were performed on 194 children with CHD (age range 10 days-15 years). Data was analysed using SPSS 16.0.
Out of 194 children studied, 53/194 (27.3 %, 95 % CI 21.0 - 33.6) children had arrhythmias. Of the CHD children, 44/194 (22.7 %, 95 % CI 16.8 - 28.6) had first degree AV block while 9/194 (4.6 %, 95 % CI 1.7 - 7.6) children had either ectopic atrial rhythm, premature atrial contractions, junctional rhythm, complete atrioventricular (AV) dissociation or premature ventricular contractions. Children using digoxin were more likely to have first degree AV block (OR 3.75, 95 % CI 1.60-8.86) while those aged 5 years and below were less likely to have first degree AV block (OR 0.16, 95 % CI 0.07-0.37).
Arrhythmias are common among children with CHD receiving care from Mulago Hospital. These are associated with digoxin use, child's age and electrolyte imbalances; factors which can easily be assessed, managed and where possible modified in these children during their care.
在乌干达,很少有先天性心脏病(CHD)患儿能从早期心脏矫正手术中获益。这些患儿发生心力衰竭和电解质失衡的风险很高;这些因素会增加他们发生心律失常的风险。本研究旨在确定在穆拉戈医院接受治疗的先天性心脏病患儿中心律失常的患病率及相关因素。
这是一项于2013年8月至2014年3月在穆拉戈医院开展的横断面研究。患儿被连续纳入研究。对194例先天性心脏病患儿(年龄范围10天至15岁)进行了标准12导联心电图(ECG)检查。使用SPSS 16.0对数据进行分析。
在研究的194例患儿中,53/194(27.3%,95%可信区间21.0 - 33.6)例患儿有心律失常。在先天性心脏病患儿中,44/194(22.7%,95%可信区间16.8 - 28.6)例有一度房室传导阻滞,而9/194(4.6%,95%可信区间1.7 - 7.6)例患儿有异位心律、房性早搏、交界性心律、完全性房室分离或室性早搏。使用地高辛的患儿更易发生一度房室传导阻滞(比值比3.75,95%可信区间1.60 - 8.86),而5岁及以下患儿发生一度房室传导阻滞的可能性较小(比值比0.16,95%可信区间0.07 - 0.37)。
在穆拉戈医院接受治疗的先天性心脏病患儿中心律失常很常见。这些与地高辛的使用、患儿年龄和电解质失衡有关;这些因素在患儿治疗期间很容易评估、管理,并在可能的情况下进行调整。