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脂多糖刺激的大鼠脑巨噬细胞在体外释放神经生长因子。

Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro.

作者信息

Mallat M, Houlgatte R, Brachet P, Prochiantz A

机构信息

INSERUM U114, Collège de France, Paris.

出版信息

Dev Biol. 1989 May;133(1):309-11. doi: 10.1016/0012-1606(89)90322-9.

DOI:10.1016/0012-1606(89)90322-9
PMID:2707484
Abstract

Amoeboid microglial cells purified from primary cultures of embryonic rat brains and stimulated with bacterial lipopolysaccharides released high amounts of nerve growth factor. This finding suggests that brain macrophages play a major neurotrophic role during development, in adulthood, and in the regenerative events that follow localized lesions.

摘要

从胚胎大鼠脑原代培养物中纯化出的阿米巴样小胶质细胞,在用细菌脂多糖刺激后会释放大量神经生长因子。这一发现表明,脑巨噬细胞在发育过程、成年期以及局部损伤后的再生过程中发挥着主要的神经营养作用。

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