间充质细胞迁移在水螅神经细胞分化的位置依赖性模式形成中的作用。
Role of interstitial cell migration in generating position-dependent patterns of nerve cell differentiation in Hydra.
作者信息
Fujisawa T
机构信息
Department of Developmental Genetics, National Institute of Genetics, Shizuoka, Japan.
出版信息
Dev Biol. 1989 May;133(1):77-82. doi: 10.1016/0012-1606(89)90298-4.
The role of interstitial cell migration in the formation of newly differentiated nerve cells was examined during head regeneration in Hydra magnipapillata. When distal tissue was removed from the body of a wild-type strain (105), nerve cell differentiation occurred at a rapid rate during the first 48 hr of regeneration, slowing after this point. Rapid nerve cell differentiation was due primarily to migration of interstitial cells, some of which appeared to be nerve cell precursors, into the regenerating head. The migration decreased considerably after the first 48 hr of regeneration. In reg-16, a mutant strain deficient in head regeneration, no migration of interstitial cells and hence no new nerve cell differentiation were observed in the regenerating tip. However, the interstitial cells of reg-16 were observed to migrate into regenerating tissue of strain 105. These observations suggest that the migration of nerve cell precursors plays an important role when the new nerve net is being established during head regeneration.
在大型乳头水螅头部再生过程中，研究了间质细胞迁移在新分化神经细胞形成中的作用。当从野生型菌株（105）的身体上移除远端组织时，在再生的最初48小时内神经细胞分化迅速发生，此后速度减慢。快速的神经细胞分化主要是由于间质细胞迁移，其中一些似乎是神经细胞前体，迁移到再生头部。再生48小时后，迁移显著减少。在reg-16（一种头部再生缺陷的突变菌株）中，在再生尖端未观察到间质细胞迁移，因此也未观察到新的神经细胞分化。然而，观察到reg-16的间质细胞迁移到105菌株的再生组织中。这些观察结果表明，在头部再生过程中建立新的神经网时，神经细胞前体的迁移起着重要作用。
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