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一例伴有脂蛋白(a)升高的主动脉血栓形成的独特病例。

A Unique Case of Aortic Thrombosis With Elevated Lipoprotein(a).

作者信息

Ostertag-Hill Claire A, Titus Jessica M, Skeik Nedaa

机构信息

Minneapolis Heart Institute Research Foundation, Minneapolis, MN

Vascular Surgery, Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN.

出版信息

Vasc Endovascular Surg. 2016 May;50(4):286-9. doi: 10.1177/1538574416642875. Epub 2016 Apr 12.

Abstract

Aortic thrombosis is a rare condition that can be caused by atherosclerosis, aneurysms, thrombophilia, vasculitis, trauma, and malignancy. Symptoms vary based on thrombus size and site of embolization. It can lead to devastating complications including acute limb ischemia, myocardial infarction, stroke, and other target organ ischemia. Diagnosis is based on clinical presentation, imaging findings, and relevant laboratory work-up. Although not well defined, management for aortic thrombosis includes surgical intervention, such as thromboembolectomy, and conservative measures, such as anticoagulation. Here, we present a unique case of aortic thrombosis causing acute lower limb ischemia with elevated lipoprotein(a) and other comorbidities. Based on our literature review, our article is the first to establish the connection between elevated lipoprotein(a) and aortic thrombosis in the nonaneurysmal aorta.

摘要

主动脉血栓形成是一种罕见的病症,可由动脉粥样硬化、动脉瘤、血栓形成倾向、血管炎、创伤和恶性肿瘤引起。症状因血栓大小和栓塞部位而异。它可导致严重的并发症,包括急性肢体缺血、心肌梗死、中风和其他靶器官缺血。诊断基于临床表现、影像学检查结果和相关实验室检查。虽然没有明确的定义,但主动脉血栓形成的治疗包括手术干预,如血栓切除术,以及保守措施,如抗凝治疗。在此,我们报告一例因脂蛋白(a)升高及其他合并症导致急性下肢缺血的主动脉血栓形成的独特病例。根据我们的文献综述,我们的文章首次在非动脉瘤性主动脉中建立了脂蛋白(a)升高与主动脉血栓形成之间的联系。

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