二氧化锰正离子/三价锰络合物与抗坏血酸盐之间的相互作用。脉冲辐解研究。

The interactions between MnO2+/Mn3+ complexes and ascorbates. A pulse radiolysis study.

作者信息

Cabelli D E

机构信息

Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973.

出版信息

Free Radic Biol Med. 1989;6(2):171-7. doi: 10.1016/0891-5849(89)90114-7.

DOI:10.1016/0891-5849(89)90114-7

PMID:2707619

Abstract

The reactivity between various MnO2+/Mn3+ complexes and ascorbic acid/ascorbate were studied using pulse radiolysis. Experimental results indicate that Mn3+-sulfate reacts with both AH2/AH- via metal-ascorbate complexes. MnO2+-formate and Mn3+-pyrophosphate both appear to react by electron transfer with no evidence of complex formation. All of these metal complexes, with the exception of Mn3+-pyrophosphate, react as fast or faster with ascorbate than free O2-. The significance of this observation in light of metal-induced oxygen toxicity will be discussed.

摘要

使用脉冲辐解研究了各种MnO2+/Mn3+配合物与抗坏血酸/抗坏血酸盐之间的反应活性。实验结果表明，硫酸锰（III）通过金属抗坏血酸盐配合物与AH2/AH-反应。甲酸根合二氧化锰（III）和焦磷酸锰（III）似乎都通过电子转移反应，没有形成配合物的证据。除焦磷酸锰（III）外，所有这些金属配合物与抗坏血酸盐反应的速度与游离超氧阴离子相当或更快。将讨论这一观察结果在金属诱导的氧毒性方面的意义。