Li Yuan, Wang Yanyun, Ding Xiaoyan, Duan Bide, Li Lei, Wang Xietong
Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China Zibo Central Hospital, Zibo, Shandong, China.
Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Reprod Sci. 2016 Oct;23(10):1402-8. doi: 10.1177/1933719116641760. Epub 2016 Apr 12.
Tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) are proinflammatory cytokines and known to be involved in many pathological processes. However, the association between serum levels of TNF-α, IL-6, and pregnancy-induced hypertension (PIH) is unclear. The aim of the present study was to determine the serum levels of TNF-α and IL-6 and to investigate their potential correlation with PIH. In this study, the serum concentrations of TNF-α and IL-6 in pregnant women who developed PIH and normal pregnant women were measured. We found that the serum concentrations of TNF-α and IL-6 were significantly increased in the patients with PIH compared to the normal pregnant women. In addition, elevated TNF-α and IL-6 concentrations were associated with pathological complications. Moreover, in a hypoxia-induced PIH mice model, animals from the PIH group demonstrated higher TNF-α and IL-6 levels when compared to control, and serum TNF-α and IL-6 levels were positively correlated with right ventricular systolic blood pressure. Furthermore, TNF-α and IL-6 levels were decreased when the PIH mice were treated with remodulin compared to control group. In conclusion, our results suggested that high serum TNF-α and IL-6 levels are associated with PIH, and TNF-α and IL-6 might be potential predictors in the prognosis of PIH.
肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）是促炎细胞因子，已知参与许多病理过程。然而，血清TNF-α、IL-6水平与妊娠高血压综合征（PIH）之间的关联尚不清楚。本研究的目的是测定TNF-α和IL-6的血清水平，并研究它们与PIH的潜在相关性。在本研究中，测量了发生PIH的孕妇和正常孕妇血清中TNF-α和IL-6的浓度。我们发现，与正常孕妇相比，PIH患者血清中TNF-α和IL-6的浓度显著升高。此外，TNF-α和IL-6浓度升高与病理并发症相关。而且，在缺氧诱导的PIH小鼠模型中，与对照组相比，PIH组动物的TNF-α和IL-6水平更高，血清TNF-α和IL-6水平与右心室收缩压呈正相关。此外，与对照组相比，用瑞莫杜林治疗PIH小鼠后，TNF-α和IL-6水平降低。总之，我们的结果表明，血清TNF-α和IL-6水平升高与PIH相关，TNF-α和IL-6可能是PIH预后的潜在预测指标。
