Dept of Pediatric Pulmonology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Dept of Radiology, Erasmus MC, Rotterdam, The Netherlands.
Eur Respir J. 2016 Jun;47(6):1706-17. doi: 10.1183/13993003.01601-2015. Epub 2016 Apr 13.
Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.
进行性囊性纤维化（CF）肺病是 CF 患者死亡的主要原因。CF 肺病始于儿童早期。按照目前的护理标准，儿童的呼吸功能基本正常，需要更敏感的预后指标来监测早期 CF 肺病。胸部 CT 是目前监测 CF 儿童和青少年肺部结构变化最敏感的影像学方法。为了在多个中心可靠地量化结构性肺病，需要对胸部 CT 方案进行标准化。SCIFI CF（CF 干预和个体化医学的标准化胸部成像框架）的成立旨在描述来自 10 个不同国家的 16 个欧洲 CF 中心的胸部 CT 图像质量和辐射剂量。我们旨在优化几个 CF 中心的儿童和青少年 CT 方案。我们发现，在中心之间，CT 方案、图像质量和辐射剂量的使用存在很大差异。然而，考虑到空间分辨率和辐射剂量，所有 CT 扫描仪的性能都非常相似。我们得出结论，在未来的临床试验中，可以实现 CF 儿童和青少年的胸部 CT 多中心标准化。
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