Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany; Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Im Neuenheimer Feld 156, 69120Heidelberg,Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, University of Heidelberg, Röntgenstrasse 1, 69126Heidelberg,Germany.
Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Im Neuenheimer Feld 156, 69120Heidelberg,Germany; Division of Pediatric Pulmonology & Allergy and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Im Neuenheimer Feld 430, 69120Heidelberg, Germany; Department of Translational Pulmonology, University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany.
J Cyst Fibros. 2018 Jul;17(4):518-527. doi: 10.1016/j.jcf.2018.05.003. Epub 2018 May 25.
A recent single-centre study demonstrated that MRI is sensitive to detect early abnormalities in the lung and response to therapy in infants and preschool children with cystic fibrosis (CF) supporting MRI as an outcome measure of early CF lung disease. However, the feasibility of multicentre standardisation remains unknown.
To determine the feasibility of multicentre standardisation of chest MRI in infants and preschool children with CF.
A standardised chest 1.5T MRI protocol was implemented across four specialised CF centres. Following training and initiation visits, 42 infants and preschool children (mean age 3.2±1.5years, range 0-6years) with clinically stable CF underwent MRI and chest X-ray (CXR). Image quality and lung abnormalities were assessed using a standardised questionnaire and an established CF MRI and CXR score.
MRI was successfully performed with diagnostic quality in all patients (100%). Incomplete lung coverage was observed in 6% and artefacts also in 6% of sequence acquisitions, but these were compensated by remaining sequences in all patients. The range of the MRI score in CF patients was similar across centres with a mean global MRI score of 13.3±5.8. Cross-validation of the MRI against the CXR score revealed a moderate correlation (r=0.43-0.50, p<0.01).
Our results demonstrate that multicentre standardisation of chest MRI is feasible and support its use as radiation-free outcome measure of lung disease in infants and preschool children with CF.
最近的一项单中心研究表明，MRI 能够敏感地检测出囊性纤维化（CF）婴儿和学龄前儿童肺部的早期异常和对治疗的反应，支持 MRI 作为 CF 肺部疾病早期的结果测量指标。然而，多中心标准化的可行性尚不清楚。
确定 CF 婴儿和学龄前儿童胸部 MRI 多中心标准化的可行性。
在四个专门的 CF 中心实施了标准化的 1.5T 胸部 MRI 方案。经过培训和启动访问后，42 名临床稳定的 CF 婴儿和学龄前儿童（平均年龄 3.2±1.5 岁，范围 0-6 岁）接受了 MRI 和胸部 X 线（CXR）检查。使用标准化问卷和既定的 CF MRI 和 CXR 评分评估图像质量和肺部异常。
所有患者（100%）均成功进行了具有诊断质量的 MRI。在 6%的患者中观察到不完全的肺部覆盖，在 6%的序列采集中有伪影，但在所有患者中，这些都可以通过剩余的序列来补偿。CF 患者的 MRI 评分范围在各中心之间相似，平均全球 MRI 评分为 13.3±5.8。MRI 与 CXR 评分的交叉验证显示出中度相关性（r=0.43-0.50，p<0.01）。
我们的结果表明，胸部 MRI 的多中心标准化是可行的，并支持其作为 CF 婴儿和学龄前儿童肺部疾病无辐射的结果测量指标。
