Prakash Sanjay, Rathore Chaturbhuj
Department of Neurology, Smt B. K. Shah Medical Institute and Research Centre Medical College, Vadodara, Gujarat, India.
Indian J Crit Care Med. 2016 Feb;20(2):120-2. doi: 10.4103/0972-5229.175944.
Serotonin syndrome (SS) is an iatrogenic, drug-induced clinical syndrome caused by serotoninergic hyperstimulation. The diagnosis of SS is easily overlooked as most physicians (up to 85%) are unaware of this syndrome as a clinical entity. Diagnosis is also difficult due to its protean manifestations which can mimic a variety of medical conditions. Herein, we describe two cases of SS, who initially presented to the Surgical Department as surgical emergencies. The first case developed urinary retention after the administration of sertraline. The second case developed features mimicking acute intestinal obstruction. Both cases responded to the removal of offending agents and administration of cyproheptadine. There is a need to increase the awareness of SS among physicians because of the widespread use of serotonergic agents all around the world.
血清素综合征（SS）是一种由血清素能过度刺激引起的医源性、药物诱导的临床综合征。血清素综合征的诊断很容易被忽视，因为大多数医生（高达85%）并不知晓这一临床实体综合征。由于其症状多变，可模仿多种病症，因此诊断也很困难。在此，我们描述两例血清素综合征病例，这两名患者最初作为外科急症被送至外科。第一例在服用舍曲林后出现尿潴留。第二例出现类似急性肠梗阻的症状。两例均通过停用致病药物并给予赛庚啶后症状得到缓解。鉴于血清素能药物在全球的广泛使用，有必要提高医生对血清素综合征的认识。
