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舍曲林治疗期间的尿踌躇和尿潴留。

Urinary hesitancy and retention during treatment with sertraline.

作者信息

Lowenstein L, Mueller E R, Sharma S, FitzGerald M P

机构信息

Division of Female Pelvic Medicine and Reconstructive Surgery, Loyola Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.

出版信息

Int Urogynecol J Pelvic Floor Dysfunct. 2007 Jul;18(7):827-9. doi: 10.1007/s00192-006-0241-4. Epub 2006 Nov 7.

DOI:10.1007/s00192-006-0241-4
PMID:17089079
Abstract

We report the cases of two women who began to experience urinary hesitancy and retention after starting treatment with sertraline for depression. Discontinuation of the drug resulted in complete symptom relief. Serotonergic neurons are involved at several levels in control of the lower urinary tract. Retention is apparently an uncommon complication of sertraline. Discontinuation should be considered for patients presenting with voiding difficulties.

摘要

我们报告了两名女性的病例,她们在开始使用舍曲林治疗抑郁症后出现了排尿犹豫和尿潴留。停药后症状完全缓解。血清素能神经元在多个层面参与下尿路的控制。尿潴留显然是舍曲林一种不常见的并发症。对于出现排尿困难的患者应考虑停药。

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Urinary hesitancy and retention during treatment with sertraline.舍曲林治疗期间的尿踌躇和尿潴留。
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Can J Psychiatry. 1998 Dec;43(10):1051-2.
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Are commonly used psychoactive medications associated with lower urinary tract symptoms?常用的精神活性药物与下尿路症状有关吗?

本文引用的文献

1
Facilitatory neuromodulative effect of duloxetine on pudendal motor neurons controlling the urethral pressure: a functional urodynamic study in healthy women.度洛西汀对控制尿道压力的阴部运动神经元的促进性神经调节作用:一项针对健康女性的功能性尿动力学研究。
Eur Urol. 2006 Jul;50(1):119-25. doi: 10.1016/j.eururo.2005.12.020. Epub 2006 Jan 18.
2
Serotonin and noradrenaline reuptake inhibitors (SNRI) for stress urinary incontinence in adults.用于治疗成人压力性尿失禁的5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRI)
Cochrane Database Syst Rev. 2005 Jul 20(3):CD004742. doi: 10.1002/14651858.CD004742.pub2.
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Urinary Side Effects of Duloxetine in the Treatment of Depression and Stress Urinary Incontinence.
Eur J Clin Pharmacol. 2012 May;68(5):783-91. doi: 10.1007/s00228-011-1170-9. Epub 2011 Dec 4.
4
Female voiding dysfunction: prevalence and common associations.女性排尿功能障碍:患病率及常见相关因素。
Curr Urol Rep. 2009 Nov;10(6):421-7. doi: 10.1007/s11934-009-0067-y.
度洛西汀治疗抑郁症和压力性尿失禁的泌尿系统副作用。
Prim Care Companion J Clin Psychiatry. 2004;6(2):65-73. doi: 10.4088/pcc.v06n0204.
4
Duloxetine vs placebo in the treatment of stress urinary incontinence: a four-continent randomized clinical trial.度洛西汀与安慰剂治疗压力性尿失禁的四洲随机临床试验
BJU Int. 2004 Feb;93(3):311-8. doi: 10.1111/j.1464-410x.2004.04607.x.
5
CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention.中枢神经系统参与膀胱过度活动症:病理生理学及药物干预机会
Drugs. 2003;63(23):2595-611. doi: 10.2165/00003495-200363230-00003.
6
Serotonin and norepinephrine involvement in efferent pathways to the urethral rhabdosphincter: implications for treating stress urinary incontinence.血清素和去甲肾上腺素在尿道横纹括约肌传出通路中的作用:对治疗压力性尿失禁的启示。
Urology. 2003 Oct;62(4 Suppl 1):3-9. doi: 10.1016/s0090-4295(03)00754-4.
7
The role of 5-HT(1A) receptors in control of lower urinary tract function in cats.5-羟色胺(1A)受体在猫下尿路功能控制中的作用。
Brain Res. 2002 Aug 16;946(2):290-7. doi: 10.1016/s0006-8993(02)02897-4.
8
Multiplicity of mechanisms of serotonin receptor signal transduction.血清素受体信号转导机制的多样性。
Pharmacol Ther. 2001 Nov-Dec;92(2-3):179-212. doi: 10.1016/s0163-7258(01)00169-3.
9
Urinary retention with sertraline, haloperidol, and clonazepam combination.舍曲林、氟哌啶醇和氯硝西泮联合使用导致尿潴留。
Can J Psychiatry. 1998 Dec;43(10):1051-2.
10
Serotonergic modulation of spinal ascending activity and sacral reflex activity evoked by pelvic nerve stimulation in cats.猫盆神经刺激诱发的脊髓上行活动和骶反射活动的5-羟色胺能调节
Brain Res. 1998 Jul 6;798(1-2):101-8. doi: 10.1016/s0006-8993(98)00401-6.