共生补充剂对非酒精性脂肪性肝病患者肝酶、C反应蛋白及超声检查结果的影响：一项临床试验
The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.
作者信息
Asgharian Atefe, Askari Gholamreza, Esmailzade Ahmad, Feizi Awat, Mohammadi Vida
机构信息
Department of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Treatment Affair, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Community Nutrition, Food Security Research Centre, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2016 Mar 10;7:59. doi: 10.4103/2008-7802.178533. eCollection 2016.
BACKGROUND
Regarding to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), concentrating on various strategies to its prevention and management seems necessary. The aim of this study was to determine the effects of symbiotic on C-reactive protein (CRP), liver enzymes, and ultrasound findings in patients with NAFLD.
METHODS
Eighty NAFLD patients were enrolled in this randomized, double-blind, placebo-controlled clinical trial. Participants received symbiotic in form of a 500 mg capsule (containing seven species of probiotic bacteria and fructooligosaccharides) or a placebo capsule daily for 8 weeks. Ultrasound grading, CRP, and liver enzymes were evaluated at the baseline and the end of the study.
RESULTS
In the symbiotic group, ultrasound grade decreased significantly compared to baseline (P < 0.005) but symbiotic supplementation was not associated with changes in alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. In the placebo group, there was no significant change in steatosis grade whereas ALT and AST levels were significantly increased (P = 0.002, P = 0.02, respectively). CRP values remained static in either group.
CONCLUSIONS
Symbiotic supplementation improved steatosis in NAFLD patients and might be useful in the management of NAFLD or protective against its progression.
背景
鉴于非酒精性脂肪性肝病（NAFLD）的患病率不断上升，关注其预防和管理的各种策略似乎很有必要。本研究的目的是确定共生菌对NAFLD患者C反应蛋白（CRP）、肝酶和超声检查结果的影响。
方法
80例NAFLD患者参与了这项随机、双盲、安慰剂对照的临床试验。参与者每天接受一粒500毫克胶囊形式的共生菌（含有七种益生菌和低聚果糖）或一粒安慰剂胶囊，持续8周。在研究基线和结束时评估超声分级、CRP和肝酶。
结果
与基线相比，共生菌组的超声分级显著降低（P < 0.005），但补充共生菌与丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平的变化无关。在安慰剂组中，脂肪变性分级无显著变化，而ALT和AST水平显著升高（分别为P = 0.002，P = 0.02）。两组的CRP值均保持不变。
结论
补充共生菌可改善NAFLD患者的脂肪变性，可能有助于NAFLD的管理或预防其进展。
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