The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.

The electronic properties of a series of N,N-dimethyltryptamines and related analogs, for which binding affinity data are available, were examined using both a pi-electron and an all-valence electron method. The results suggest that affinity is related to the ability of these compounds to donate electrons in a localized charge transfer manner from the 4-position of the indole nucleus.