• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.

作者信息

Glennon R A, Gessner P K

出版信息

Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):453-65.

PMID:270770
Abstract

The electronic properties of a series of N,N-dimethyltryptamines and related analogs, for which binding affinity data are available, were examined using both a pi-electron and an all-valence electron method. The results suggest that affinity is related to the ability of these compounds to donate electrons in a localized charge transfer manner from the 4-position of the indole nucleus.

摘要

相似文献

1
The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs.
Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):453-65.
2
Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives.致幻性N,N-二烷基色胺的构效关系：甲硫基和亚甲二氧基衍生物的光电子能谱及5-羟色胺受体亲和力
J Med Chem. 1982 Nov;25(11):1381-3. doi: 10.1021/jm00353a021.
3
Studies on several 7-substituted N,N-dimethyltryptamines.几种7-取代的N,N-二甲基色胺的研究。
J Med Chem. 1980 Nov;23(11):1222-6. doi: 10.1021/jm00185a014.
4
Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.几种致幻性苯烷基胺和N,N-二甲基色胺类似物的血清素受体结合亲和力。
J Med Chem. 1978 Aug;21(8):822-5. doi: 10.1021/jm00206a022.
5
Evidence for and against the involvement of N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in schizophrenia.
Psychopharmacol Bull. 1976 Oct;12(4):12-3.
6
A quantum chemical investigation of the pi-electronic structure of the hallucinogenic N,N-dimethyltryptamines.
Res Commun Chem Pathol Pharmacol. 1974 Sep;9(1):185-8.
7
Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors.一系列α-甲基色胺对映体的合成及其对血清素受体的亲和力：色胺在血清素5-HT1B受体上结合构象的证据
J Med Chem. 1988 Jul;31(7):1406-12. doi: 10.1021/jm00402a026.
8
In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat.大鼠体内5-甲氧基-N,N-二甲基色胺和N,N-二甲基色胺的代谢
Biochem Pharmacol. 1987 May 1;36(9):1509-12. doi: 10.1016/0006-2952(87)90118-3.
9
Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites.一些构象受限色胺类似物在5-羟色胺1、5-羟色胺1A和5-羟色胺2识别位点的相对选择性。
Life Sci. 1987 Oct 19;41(16):1961-9. doi: 10.1016/0024-3205(87)90749-1.
10
Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography.利用液相色谱法对大鼠组织提取物中拟精神病吲哚烷基胺的代谢研究
Biochem Pharmacol. 1987 May 1;36(9):1503-8. doi: 10.1016/0006-2952(87)90117-1.

引用本文的文献

1
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents - A Review.1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI）：从一种鲜为人知的物质到血清素致幻剂DOX家族的关键成员——综述
ACS Pharmacol Transl Sci. 2024 May 8;7(6):1722-1745. doi: 10.1021/acsptsci.4c00157. eCollection 2024 Jun 14.
2
Electron-transfer and charge-transfer clastic binding hypotheses for drug-receptor interactions.药物 - 受体相互作用的电子转移和电荷转移弹性结合假说。
Pharm Res. 1987 Dec;4(6):450-6. doi: 10.1023/a:1016415202819.