Electron-transfer and charge-transfer clastic binding hypotheses for drug-receptor interactions.

The origins and development of clastic binding hypotheses for interaction of morphines with the opiate receptor and various hallucinogens with their putative receptors are reviewed. Possible alternative explanations of the facts which led to the clastic binding hypotheses are offered. Possible integration of the clastic binding processes into other, better-recognized processes at the receptors is considered.