药物 - 受体相互作用的电子转移和电荷转移弹性结合假说。

Electron-transfer and charge-transfer clastic binding hypotheses for drug-receptor interactions.

作者信息

Kolb V M

机构信息

Department of Chemistry, University of Wisconsin--Parkside, Kenosha 53141.

出版信息

Pharm Res. 1987 Dec;4(6):450-6. doi: 10.1023/a:1016415202819.

DOI:10.1023/a:1016415202819

PMID:3334168

Abstract

The origins and development of clastic binding hypotheses for interaction of morphines with the opiate receptor and various hallucinogens with their putative receptors are reviewed. Possible alternative explanations of the facts which led to the clastic binding hypotheses are offered. Possible integration of the clastic binding processes into other, better-recognized processes at the receptors is considered.

摘要

本文综述了吗啡与阿片受体相互作用以及各种致幻剂与其假定受体相互作用的弹性结合假说的起源和发展。针对导致弹性结合假说的事实，提供了可能的其他解释。探讨了将弹性结合过程整合到受体处其他更被认可的过程中的可能性。