Bustos Patricia, Amigo Hugo, Bangdiwala Shrikant I, Pizarro Tito, Rona Roberto J
aDepartment of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile bDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, USA cMinistry of Health of Chile, Santiago, Chile dDepartment of Psychological Medicine, Weston Education Centre, King's College London, London, UK.
J Hypertens. 2016 Jun;34(6):1062-7. doi: 10.1097/HJH.0000000000000912.
To assess whether the association between birth weight and blood pressure (BP) increases with age using three different statistical methods.
A representative sample of 1232 study participants born between 1974-1978 in Limache, Chile were assessed in 2000-2002, of whom 796 were reassessed in 2010-2012. An 'amplification effect' was assessed by the change in the β coefficient in the two periods, the association between birth weight and the difference of BP overtime, and the interaction between birth weight and BP in the two periods.
Birth weight was negatively associated with SBP in 2000-2002 (β = -2.46, 95% confidence interval (CI) -3.77 to -1.16) and in 2010-2012 (β = -3.64, 95% CI -5.20 to -2.08), and with DBP in 2000-2002 (β = -1.26, 95% CI -2.23 to -0.29) , and 2010-2012 (β = -1.64, 95% CI -2.84 to -0.45) after adjustment for sex, physical activity, and BMI. There was no association between birth weight and the difference in BP between the two periods or the interaction between birth weight, BP, and time interval.
Birth weight is a factor associated with BP in adults. This association increased with age, but amplification was shown only with one of the three methods.
使用三种不同的统计方法评估出生体重与血压（BP）之间的关联是否随年龄增长而增强。
对1974年至1978年出生在智利利马切的1232名研究参与者的代表性样本在2000年至2002年进行评估，其中796人在2010年至2012年进行了重新评估。通过两个时期β系数的变化、出生体重与血压随时间变化差异之间的关联以及两个时期出生体重与血压之间的相互作用来评估“放大效应”。
在调整性别、身体活动和体重指数后，2000年至2002年出生体重与收缩压呈负相关（β=-2.46，95%置信区间（CI）-3.77至-1.16），2010年至2012年也呈负相关（β=-3.64，95%CI-5.20至-2.08）；2000年至2002年出生体重与舒张压呈负相关（β=-1.26，95%CI-2.23至-0.29），2010年至2012年也呈负相关（β=-1.64，95%CI-2.84至-0.45）。出生体重与两个时期血压差异之间或出生体重、血压和时间间隔之间的相互作用无关联。
出生体重是与成年人血压相关的一个因素。这种关联随年龄增长而增强，但仅在三种方法中的一种中显示出放大效应。
